Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4076229 | 0.91 | NPSR1 (0.39) | NPSR1HPGDTSHRMAPK1ATM | |
| SCHEMBL4072533 | 0.82 | ALOX5 (0.39) | LMNAPOLBAPLNRGAAALDH1A1 | |
| SCHEMBL15061654 | 0.77 | NPSR1 (0.45) | NPSR1HPGDTSHRMAPK1ATM | |
| SCHEMBL6492852 | 0.76 | NPSR1 (0.47) | NPSR1HPGDTSHRMAPK1ATM | |
| SCHEMBL4150440 | 0.74 | NPSR1 (0.47) | NPSR1HPGDTSHRMAPK1ATM | |
| SCHEMBL6385504 | 0.74 | CA1 (0.45) | TSHRKDM4EMAPTGAAALDH1A1 | |
| SCHEMBL2403566 | 0.73 | NPSR1 (0.53) | NPSR1HPGDTSHRMAPK1ATM | |
| SCHEMBL23791955 | 0.72 | ALDH1A1 (0.38) | NPSR1HPGDTSHRMAPK1ATM | |
| SCHEMBL7585603 | 0.72 | TSHR (0.41) | HPGDTSHRATMLMNAKDM4E | |
| SCHEMBL2654349 | 0.72 | NPSR1 (0.51) | NPSR1HPGDTSHRMAPK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440553-B1 | THIOPHENES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE | MERCK SHARP & DOHME (US) | 2017-08-23 | — | — | EP | disclosed |
| US-8470773-B2 | Thiophenes as glucagon receptor antagonists, compositions, and methods for their use | MERCK SHARP & DOHME CORP. (US) | 2013-06-25 | — | — | US | disclosed |