Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15076174 | 0.84 | IDO1 (0.47) | IDO1TDP1LMNAKMT2AMEN1 | |
| SCHEMBL17955422 | 0.81 | CYP1A2 (0.56) | IDO1TDP1LMNAKMT2AMEN1 | |
| SCHEMBL9020977 | 0.79 | MEN1 (0.44) | IDO1LMNAKMT2AMEN1MAPK1 | |
| SCHEMBL29701155 | 0.79 | HTT (0.64) | IDO1LMNAKMT2AMEN1MAPK1 | |
| SCHEMBL15062006 | 0.75 | IDO1 (0.46) | IDO1LMNAMAPTHTTTHRB | |
| SCHEMBL12676724 | 0.74 | IDO1 (0.63) | IDO1LMNAKMT2AMEN1MAPK1 | |
| SCHEMBL1592876 | 0.73 | TDP1 (0.60) | TDP1LMNAKMT2AMEN1HPGD | |
| SCHEMBL11866 | 0.73 | KMT2A (0.56) | TDP1LMNAKMT2AMEN1MAPK1 | |
| SCHEMBL17955455 | 0.73 | IDO1 (0.45) | IDO1TDP1LMNAKMT2AMEN1 | |
| SCHEMBL25783849 | 0.72 | IDO1 (0.46) | IDO1LMNAKMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013091773-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |
| EP-2607364-A1 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | Ares Trading S.A. (CH) | 2013-06-26 | — | — | EP | disclosed |