Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27749715 | 0.90 | KMT2A (0.59) | KMT2ASMN1; SMN2CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL9020973 | 0.84 | KMT2A (0.52) | KMT2ASMN1; SMN2CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL12449586 | 0.82 | LMNA (0.52) | KMT2ASMN1; SMN2RAB9AKDM4EL3MBTL1 | |
| SCHEMBL14163851 | 0.80 | KMT2A (0.58) | KMT2ASMN1; SMN2CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL14136068 | 0.77 | ALDH1A1 (0.57) | KMT2ASMN1; SMN2TSHRTDP1KDM4E | |
| SCHEMBL12382 | 0.75 | KMT2A (0.87) | KMT2ASMN1; SMN2CYP2C9CYP1A2CYP3A4 | |
| SCHEMBL27465 | 0.75 | DRD2 (0.62) | KMT2ASMN1; SMN2RAB9ATDP1KDM4E | |
| SCHEMBL29381067 | 0.75 | DRD2 (0.62) | KMT2ASMN1; SMN2RAB9ATDP1KDM4E | |
| SCHEMBL3861581 | 0.74 | LTA4H (0.45) | KMT2ASMN1; SMN2TSHRRAB9ATDP1 | |
| SCHEMBL1355763 | 0.74 | IDO1 (0.44) | SMN1; SMN2CYP2C9CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| US-20120220590-A1 | NOVEL COMPOUNDS AS MODULATORS OF GLUCOCORTICOID RECEPTORS | KAROBIOAB (SE) | 2012-08-30 | — | — | US | disclosed |
| US-20120220590-A1 | NOVEL COMPOUNDS AS MODULATORS OF GLUCOCORTICOID RECEPTORS | KAROBIOAB (SE) | 2012-08-30 | — | — | US | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011016050-A2 | NOVEL COMPOUNDS AS MODULATORS OF GLUCOCORTICOID RECEPTORS | CADILA HEALTHCARE LIMITED (IN) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220590-A1 | NOVEL COMPOUNDS AS MODULATORS OF GLUCOCORTICOID RECEPTORS | NR3C1, NR3C2, MC2R | KMT2A 4368/4885SMN1; SMN2 4792/4885CYP2C9 1162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.