Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.50 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22545206 | 0.91 | HRH3 (0.48) | HRH3SCDEPHX2 | |
| SCHEMBL20068827 | 0.83 | SSTR4 (0.44) | HRH3 | |
| SCHEMBL14983623 | 0.83 | HRH3 (0.49) | HRH3 | |
| SCHEMBL15062011 | 0.82 | HRH3 (0.46) | HRH3SCD | |
| SCHEMBL10274501 | 0.81 | SCD (0.53) | HRH3SCDEPHX2 | |
| SCHEMBL30656257 | 0.81 | SCD (0.53) | HRH3SCDEPHX2 | |
| SCHEMBL19527552 | 0.81 | HRH3 (0.48) | HRH3 | |
| SCHEMBL10035281 | 0.80 | SLC6A2 (0.51) | SCDEPHX2 | |
| SCHEMBL17955444 | 0.80 | RBP4 (0.53) | HRH3SCD | |
| SCHEMBL20152044 | 0.79 | HRH3 (0.58) | HRH3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794608-B1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2016-09-14 | — | — | EP | disclosed |
| WO-2013091773-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |
| EP-2607364-A1 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | Ares Trading S.A. (CH) | 2013-06-26 | — | — | EP | disclosed |