Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.46 |
| ▸ | SCD | O00767 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15062019 | 0.92 | HRH3 (0.45) | HRH3SCDHRH1CCR3 | |
| SCHEMBL15062012 | 0.92 | HRH3 (0.45) | HRH3SCDHRH1CCR3 | |
| SCHEMBL15061995 | 0.84 | SCD (0.47) | HRH3SCD | |
| SCHEMBL24925309 | 0.83 | SCD (0.44) | SCD | |
| SCHEMBL17955453 | 0.82 | HRH3 (0.42) | HRH3SCD | |
| SCHEMBL15062002 | 0.82 | HRH3 (0.50) | HRH3SCD | |
| SCHEMBL24925307 | 0.80 | EIF4E (0.43) | SCD | |
| SCHEMBL15062023 | 0.79 | HTR2C (0.54) | SCD | |
| SCHEMBL15062015 | 0.79 | HTR2C (0.54) | SCD | |
| SCHEMBL15076169 | 0.78 | GPR6 (0.45) | SCDHRH1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794608-B1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2016-09-14 | — | — | EP | disclosed |
| WO-2013091773-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |
| EP-2607364-A1 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | Ares Trading S.A. (CH) | 2013-06-26 | — | — | EP | disclosed |