Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 2/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15062019 | 1.00 | HRH3 (0.45) | HRH3SLC6A4SCDHRH1CCR3 | |
| SCHEMBL15062011 | 0.92 | HRH3 (0.46) | HRH3SCDHRH1CCR3 | |
| SCHEMBL1927682 | 0.85 | SCD (0.47) | HRH3SLC6A4SCD | |
| SCHEMBL17955442 | 0.83 | SLC6A4 (0.43) | HRH3SLC6A4SCDHTR2CHTR2B | |
| SCHEMBL17955447 | 0.83 | SLC6A4 (0.43) | HRH3SLC6A4SCDHTR2CHTR2B | |
| SCHEMBL15062023 | 0.83 | HTR2C (0.54) | SLC6A4SCDHTR2CHTR2BOXTR | |
| SCHEMBL22545206 | 0.83 | HRH3 (0.48) | HRH3SCDOXTRAVPR1APDE9A | |
| SCHEMBL15062015 | 0.83 | HTR2C (0.54) | SLC6A4SCDHTR2CHTR2BOXTR | |
| SCHEMBL1928720 | 0.83 | SLC6A4 (0.43) | HRH3SLC6A4SCDHRH1CCR3 | |
| SCHEMBL15061995 | 0.81 | SCD (0.47) | HRH3SCDHTR2CHTR2BOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013091773-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |
| EP-2607364-A1 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | Ares Trading S.A. (CH) | 2013-06-26 | — | — | EP | disclosed |