Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | HTR2B | P41595 | 3/20 | 0.54 |
| ▸ | SCD | O00767 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | OXTR | P30559 | 2/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15062015 | 1.00 | HTR2C (0.54) | HTR2CHTR2BSCDKMT2ASLC6A4 | |
| SCHEMBL15061995 | 0.92 | SCD (0.47) | HTR2CHTR2BSCDKMT2AOXTR | |
| SCHEMBL15062012 | 0.83 | HRH3 (0.45) | HTR2CHTR2BSCDSLC6A4OXTR | |
| SCHEMBL15062019 | 0.83 | HRH3 (0.45) | HTR2CHTR2BSCDSLC6A4OXTR | |
| SCHEMBL24925309 | 0.82 | SCD (0.44) | SCDSLC6A4OXTRAVPR1AAVPR2 | |
| SCHEMBL5742260 | 0.82 | HTR2C (0.46) | HTR2CHTR2BSLC6A4 | |
| SCHEMBL5741834 | 0.82 | HTR2C (0.46) | HTR2CHTR2BSLC6A4 | |
| SCHEMBL17955439 | 0.81 | HTR2C (0.51) | HTR2CHTR2BKMT2A | |
| SCHEMBL17955466 | 0.81 | HTR2C (0.51) | HTR2CHTR2BKMT2A | |
| SCHEMBL10260935 | 0.81 | PDE10A (0.51) | HTR2CHTR2BSCDPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013091773-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |
| EP-2607364-A1 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | Ares Trading S.A. (CH) | 2013-06-26 | — | — | EP | disclosed |