SCHEMBL15062379

SCHEMBL15062379

COc1cc2c(OC(C)=O)c(C)n(C(=O)c3csc(SC(F)F)c3)c2cc1F

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.31
PTGS2 P35354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15062691 0.90 PTGS1 (0.42) PTGS1PTGS2
SCHEMBL15062623 0.89
SCHEMBL15062722 0.86 PTGS1 (0.30) PTGS1PTGS2
SCHEMBL15062739 0.84
SCHEMBL2006619 0.83 PTGS1 (0.50) PTGS1PTGS2
SCHEMBL15062452 0.83 TUBB1 (0.30)
SCHEMBL15062738 0.83
SCHEMBL15062537 0.80 PTGS2 (0.31) PTGS1PTGS2
SCHEMBL5553765 0.78 AKR1C3 (0.45) PTGS1PTGS2
SCHEMBL15062578 0.78 PTGS1 (0.42) PTGS1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2610244-A1 Indole compounds Ironwood Pharmaceuticals, Inc. (US) 2013-07-03 EP disclosed