Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560537 | 0.89 | AKR1C3 (0.47) | AKR1C3AKR1C2PTGS2PTGS1KDM4E | |
| SCHEMBL5822660 | 0.83 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS2PTGS1MAPT | |
| SCHEMBL5798784 | 0.80 | PTGS2 (0.66) | AKR1C3AKR1C2PTGS2PTGS1MAPT | |
| SCHEMBL5553811 | 0.80 | MAPT (0.40) | AKR1C3AKR1C2PTGS2GAAMAPT | |
| SCHEMBL5800794 | 0.80 | PTGS2 (0.37) | AKR1C3AKR1C2PTGS2PTGS1ABCB1 | |
| SCHEMBL3002102 | 0.79 | AKR1C3 (0.72) | AKR1C3AKR1C2PTGS2PTGS1MAPT | |
| SCHEMBL2002678 | 0.79 | AKR1C3 (0.47) | AKR1C3AKR1C2PTGS2PTGS1LMNA | |
| SCHEMBL5800598 | 0.79 | AKR1C3 (0.43) | AKR1C3AKR1C2PTGS2GAAMAPT | |
| SCHEMBL5823303 | 0.79 | AKR1C3 (0.43) | AKR1C3AKR1C2PTGS2PTGS1KDM4E | |
| SCHEMBL15062379 | 0.78 | PTGS1 (0.31) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006050120-A2 | SYNTHESIS OF COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |