Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.35 |
| ▸ | NGFR | P08138 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2997835 | 0.81 | DAO (0.45) | DAOBRAFTNNI3KTSHRALOX15 | |
| SCHEMBL3006533 | 0.81 | DAO (0.45) | DAOBRAFTNNI3KTSHRALOX15 | |
| SCHEMBL2199156 | 0.77 | KDM4E (0.43) | BRAFALOX15SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL12684263 | 0.75 | DAO (0.42) | DAOTSHRALOX15NFKB1BLM | |
| SCHEMBL7976646 | 0.74 | DAO (0.45) | DAOBRAFTNNI3KALOX15NFKB1 | |
| SCHEMBL3647958 | 0.72 | TRPA1 (0.44) | — | |
| SCHEMBL14609650 | 0.70 | CSF1R (0.49) | BRAFTNNI3KNGFR | |
| SCHEMBL3007329 | 0.69 | DAO (0.37) | DAOTSHRALOX15NFKB1BLM | |
| SCHEMBL23147745 | 0.69 | NUDT1 (0.44) | DAOBRAFTNNI3KIDO1TDO2 | |
| SCHEMBL22554070 | 0.69 | DAO (0.44) | DAOBRAFTNNI3KALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| CN-102850324-A | Indole compounds | MICROBIA INC | 2013-01-02 | — | — | CN | disclosed |
| CN-101563337-A | Indole compounds | MICROBIA INC (US) | 2009-10-21 | — | — | CN | disclosed |