Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CD4 | P01730 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3088274 | 0.85 | KMT2A (0.37) | KMT2AMEN1MAPK1CD4PKM | |
| SCHEMBL3088638 | 0.80 | KMT2A (0.44) | KMT2AMEN1MAPK1ALDH1A1TP53 | |
| SCHEMBL3724021 | 0.77 | KMT2A (0.36) | KMT2AMEN1MAPK1PKMSMN1; SMN2 | |
| SCHEMBL3082544 | 0.72 | KMT2A (0.37) | KMT2AMEN1MAPK1PKMSMN1; SMN2 | |
| SCHEMBL15062809 | 0.71 | AKR1C3 (0.58) | KMT2AMEN1PKMSMN1; SMN2L3MBTL1 | |
| SCHEMBL3096365 | 0.71 | CYP3A4 (0.51) | KMT2AMAPK1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL4436606 | 0.70 | HSD17B10 (0.34) | TP53 | |
| SCHEMBL15062737 | 0.70 | AKR1C3 (0.46) | PKMSMN1; SMN2ALDH1A1L3MBTL1AKR1C3 | |
| SCHEMBL3095457 | 0.69 | POLB (0.41) | KMT2AMEN1MAPK1PKMSMN1; SMN2 | |
| SCHEMBL15062759 | 0.69 | CHRM3 (0.38) | KMT2AMEN1MAPK1CD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393812-B1 | SUBSTITUTED SPIROAMIDES AS B1R-MODULATORS | GRUENENTHAL GMBH (DE) | 2013-07-03 | — | — | EP | disclosed |