Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3308376 | 0.76 | HDAC6 (0.41) | HDAC6CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL31165594 | 0.73 | LMNA (0.43) | HSD17B10HPGDHDAC6CHRM2CHRM4 | |
| SCHEMBL31125632 | 0.72 | NAMPT (0.44) | HPGDHDAC6P2RX7 | |
| SCHEMBL4435022 | 0.72 | TP53 (0.36) | HSD17B10TP53HPGDLMNA | |
| SCHEMBL4430930 | 0.71 | TP53 (0.32) | HSD17B10TP53HPGD | |
| Lithium Ion SCHEMBL31186072 | 0.71 | HDAC6 (0.40) | HDAC6CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL15062702 | 0.70 | KMT2A (0.36) | TP53 | |
| SCHEMBL2929727 | 0.70 | SMO (0.49) | HSD17B10TP53HPGD | |
| SCHEMBL8011255 | 0.70 | P2RX7 (0.43) | CHRM2CHRM3P2RX7 | |
| SCHEMBL21018833 | 0.68 | HRH4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132193-B1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INT (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2132193-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | Boehringer Ingelheim International GmbH (DE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008116881-A1 | SUBSTITUTED PYRROLIDINE AMIDES, THE PRODUCTION THEREOF, AND THE USE THEREOF AS MEDICATIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-02 | — | — | WO | disclosed |