Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL428508 | 0.78 | GBA1 (0.50) | CYP19A1KMT2A | |
| SCHEMBL1119520 | 0.78 | SLC6A2 (0.46) | SLC6A2SLC6A4HTR2ATAAR1IDO1 | |
| Ammonia Solution, Strong SCHEMBL987776 | 0.76 | SLC6A2 (0.45) | SLC6A2SLC6A4HTR2ATAAR1IDO1 | |
| SCHEMBL2785808 | 0.75 | POLB (0.46) | POLBCYP19A1MDM2HTR2ATAAR1 | |
| SCHEMBL10699635 | 0.75 | POLB (0.41) | POLB | |
| SCHEMBL23574239 | 0.74 | SLC6A2 (0.44) | SLC6A2SLC6A4KMT2A | |
| SCHEMBL6770189 | 0.74 | KMT2A (0.46) | SLC6A2SLC6A4KMT2A | |
| SCHEMBL24622493 | 0.73 | SLC6A2 (0.41) | SLC6A2SLC6A4HTR2ATAAR1IDO1 | |
| SCHEMBL16572190 | 0.72 | NPC1 (0.39) | POLBCYP19A1MDM2SLC6A2SLC6A4 | |
| SCHEMBL19110509 | 0.72 | LTA4H (0.46) | SLC6A2SLC6A4KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888523-B1 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LAB (US) | 2011-10-26 | — | — | EP | disclosed |
| EP-2298734-A2 | Cyclobutyl amine derivatives | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20090227593-A1 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-09-10 | — | — | US | disclosed |
| US-7553964-B2 | Cyclobutyl amine derivatives | ABBOTT LABORATORIES (US) | 2009-06-30 | — | — | US | disclosed |
| EP-1888523-A2 | CYCLOBUTYL AMINE DERIVATIVES | Abbott Laboratories (US) | 2008-02-20 | — | — | EP | disclosed |
| US-20070078133-A1 | Cyclobutyl amine derivatives | ABBVIE INC. | 2007-04-05 | — | — | US | disclosed |
| WO-2006132914-A2 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227593-A1 | CYCLOBUTYL AMINE DERIVATIVES | HRH2, HRH4, HRH3 | POLB 3195/4885CYP19A1 1530/4885MDM2 4468/4885 |
| US-20070078133-A1 | Cyclobutyl amine derivatives | HRH2, HRH4, HRH3 | POLB 3195/4885CYP19A1 1530/4885MDM2 4468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.