Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 7/20 | 1.00 |
| ▸ | SLC5A2 | P31639 | 7/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 2/20 | 1.00 |
| ▸ | RELA | Q04206 | 2/20 | 1.00 |
| ▸ | SLC28A3 | Q9HAS3 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | THRB | P10828 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | SLC16A3 | O15427 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phloretin SCHEMBL38131 | 1.00 | SLC5A1 (1.00) | SLC5A1SLC5A2CYP19A1MAPTHSD17B10 | |
| Phloretin SCHEMBL31684375 | 0.98 | SLC5A1 (0.96) | SLC5A1SLC5A2CYP19A1MAPTHSD17B10 | |
| Phloretin SCHEMBL30912872 | 0.98 | SLC5A1 (0.96) | SLC5A1SLC5A2CYP19A1MAPTHSD17B10 | |
| Phloretin SCHEMBL30785809 | 0.98 | SLC5A1 (0.96) | SLC5A1SLC5A2CYP19A1MAPTHSD17B10 | |
| Phloretin SCHEMBL27910960 | 0.96 | SLC5A1 (0.93) | SLC5A1SLC5A2CYP19A1MAPTHSD17B10 | |
| Phloretin SCHEMBL28362318 | 0.93 | SLC5A1 (0.87) | SLC5A1SLC5A2CYP19A1MAPTHSD17B10 | |
| Phloretin SCHEMBL30603791 | 0.93 | SLC5A1 (0.87) | SLC5A1SLC5A2CYP19A1MAPTHSD17B10 | |
| Phloretin SCHEMBL21192491 | 0.93 | SLC5A1 (0.87) | SLC5A1SLC5A2CYP19A1MAPTHSD17B10 | |
| Phloretin SCHEMBL6402644 | 0.93 | SLC5A1 (0.87) | SLC5A1SLC5A2CYP19A1MAPTHSD17B10 | |
| Phloretin SCHEMBL27906064 | 0.93 | SLC5A1 (0.87) | SLC5A1SLC5A2CYP19A1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108060165-B | Alpha-subunit-combined F1F0-ATP synthetase RNA inhibitor and application thereof | 浙江大学 | 2021-03-02 | — | — | CN | disclosed |
| CN-108486117-B | RNA inhibitor and application thereof in inhibiting activity of F1F0-ATP synthetase | 浙江大学 | 2020-09-08 | — | — | CN | disclosed |
| US-20190214145-A1 | Method and systems for creating and screening patient metabolite profile to diagnose current medical condition, diagnose current treatment state and recommend new treatment regimen | KUREK ITZHAK (US) | 2019-07-11 | — | — | US | disclosed |
| CN-107694704-B | A kind of chemical industry prepares raw material grinding device with phloretin | 东营明德化工有限公司 | 2019-06-14 | — | — | CN | disclosed |
| CN-108486117-A | A kind of RNA inhibitor and its application in inhibiting F1F0-ATP synthase activities | 浙江大学 | 2018-09-04 | — | — | CN | disclosed |
| CN-108384814-A | A kind of preparation method of phloretin | 重庆大学 | 2018-08-10 | — | — | CN | disclosed |
| CN-108060165-A | A kind of F1F0-ATP synthetase RNA (Ribonucleic Acid)s inhibitor of combination α subunits and application | 浙江大学 | 2018-05-22 | — | — | CN | disclosed |
| CN-107694704-A | A kind of chemical industry phloretin preparing raw material reducing mechanism | 徐州蓝湖信息科技有限公司 | 2018-02-16 | — | — | CN | disclosed |
| WO-2017187352-A1 | MOFEZOLAC DERIVATIVES AS MULTI-FUNCTIONS SELECTIVE COX-1 INHIBITORS | UNIVERSITA' DEGLI STUDI DI BARI "ALDO MORO" (IT) | 2017-11-02 | — | — | WO | disclosed |
| CN-104825452-B | The application of urea hydrolytic velocity inhibitor | 北京大学 | 2017-08-11 | — | — | CN | disclosed |
| CN-104825452-A | Application of urea transporter (UT) inhibitor Youli | UNIV BEIJING | 2015-08-12 | — | — | CN | disclosed |
| US-20110076239-A1 | REDUCED-SWEETENER PRODUCTS, FLAVORING MIXTURES FOR SAID REDUCED-SWEETENER PRODUCTS AND PROCESS FOR THE PRODUCTION OF PRODUCTS OF THIS TYPE | SYMRISE AG (DE) | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110076239-A1 | REDUCED-SWEETENER PRODUCTS, FLAVORING MIXTURES FOR SAID REDUCED-SWEETENER PRODUCTS AND PROCESS FOR THE PRODUCTION OF PRODUCTS OF THIS TYPE | TAS2R30, TAS2R40, TAS2R60 | SLC5A1 67/4885SLC5A2 32/4885CYP19A1 4783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.