Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | FOS | P01100 | 1/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL413254 | 0.86 | LMNA (0.81) | LMNAALOX15PLA2G4BPTPN7PPARG | |
| SCHEMBL7872215 | 0.85 | LMNA (0.70) | LMNAALOX15PLA2G4BPTPN7PPARG | |
| SCHEMBL2967940 | 0.84 | TRIM24 (0.55) | LMNANR1H4FOSJUNHTR1D | |
| SCHEMBL15063418 | 0.81 | PPARA (0.56) | LMNANR1H4PPARGPPARAMTNR1A | |
| SCHEMBL15063356 | 0.81 | LMNA (0.74) | LMNAALOX15PLA2G4BPTPN7PPARG | |
| SCHEMBL594554 | 0.81 | LMNA (1.00) | LMNAALOX15PLA2G4BPTPN7PPARG | |
| SCHEMBL30785439 | 0.81 | LMNA (1.00) | LMNAALOX15PLA2G4BPTPN7PPARG | |
| SCHEMBL11805244 | 0.81 | PLA2G4B (0.52) | PLA2G4BNR1H4PPARGPPARAFOS | |
| SCHEMBL10202711 | 0.81 | PPARA (0.59) | LMNAALOX15PLA2G4BPTPN7PPARG | |
| SCHEMBL5517321 | 0.80 | LMNA (0.63) | LMNAALOX15PLA2G4BPTPN7PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9540332-B2 | Benzimidazole derivatives as selective blockers of persistent sodium current | ALLERGAN, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-9540332-B2 | Benzimidazole derivatives as selective blockers of persistent sodium current | ALLERGAN, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-9540332-B2 | Benzimidazole derivatives as selective blockers of persistent sodium current | ALLERGAN, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20160355485-A9 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ORGANIC SOLUTIONS, INC. | 2016-12-08 | — | — | US | disclosed |
| US-20160355485-A9 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ORGANIC SOLUTIONS, INC. | 2016-12-08 | — | — | US | disclosed |
| US-20160355485-A9 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ORGANIC SOLUTIONS, INC. | 2016-12-08 | — | — | US | disclosed |
| US-20150011591-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN INC (US) | 2015-01-08 | — | — | US | disclosed |
| US-20150011591-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN INC (US) | 2015-01-08 | — | — | US | disclosed |
| US-20150011591-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN INC (US) | 2015-01-08 | — | — | US | disclosed |
| EP-2809656-A2 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN, INC. (US) | 2014-12-10 | — | — | EP | disclosed |
| US-8859780-B2 | Benzimidazole derivatives as selective blockers of persistent sodium current | ALLERGAN, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859780-B2 | Benzimidazole derivatives as selective blockers of persistent sodium current | ALLERGAN, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859780-B2 | Benzimidazole derivatives as selective blockers of persistent sodium current | ALLERGAN, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20130172389-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLEGAN, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-20130172389-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLEGAN, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-20130172389-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLEGAN, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| WO-2013101911-A2 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN, INC. (US) | 2013-07-04 | — | — | WO | disclosed |
| WO-2013101911-A2 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | ALLERGAN, INC. (US) | 2013-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011591-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | SCN1B, CACNA1E, SCN2B | LMNA 3019/4885ALOX15 3203/4885PLA2G4B 1405/4885 |
| US-20130172389-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | SCN1B, CACNA1E, SCN2B | LMNA 3019/4885ALOX15 3203/4885PLA2G4B 1405/4885 |
| US-20160355485-A9 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT | SCN1B, CACNA1E, SCN2B | LMNA 3019/4885ALOX15 3203/4885PLA2G4B 1405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.