Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 12/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.44 |
| ▸ | ABL1 | P00519 | 11/20 | 0.44 |
| ▸ | EGFR | P00533 | 11/20 | 0.44 |
| ▸ | HCK | P08631 | 11/20 | 0.44 |
| ▸ | SRC | P12931 | 11/20 | 0.44 |
| ▸ | KDR | P35968 | 11/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.44 |
| ▸ | MTOR | P42345 | 11/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 11/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 11/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15064402 | 0.82 | KDM4E (0.51) | PRKDCPIK3CDABL1EGFRHCK | |
| SCHEMBL570560 | 0.79 | ESR1 (0.42) | ESR1KDM4EALDH1A1GRIN2B | |
| SCHEMBL570307 | 0.78 | TGFBR1 (0.37) | ESR1KDM4EALDH1A1GRIN2B | |
| SCHEMBL18561572 | 0.77 | KDR (0.47) | PRKDCPIK3CDABL1EGFRHCK | |
| SCHEMBL12987576 | 0.67 | GABRG2 (0.44) | PIK3CDPIK3CAMTORESR1 | |
| SCHEMBL15064660 | 0.66 | KDR (0.37) | PRKDCPIK3CDABL1EGFRHCK | |
| SCHEMBL4030477 | 0.65 | ESR1 (0.70) | PRKDCPIK3CDABL1EGFRHCK | |
| SCHEMBL31617224 | 0.64 | PTGDR2 (0.40) | PRKDCPIK3CDABL1EGFRHCK | |
| SCHEMBL21051513 | 0.63 | ESR1 (0.42) | PRKDCPIK3CDABL1EGFRHCK | |
| SCHEMBL569294 | 0.63 | PDE1A (0.39) | PRKDCPIK3CDABL1EGFRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601192-B1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICALS CO (JP) | 2017-03-01 | — | — | EP | disclosed |
| US-9029536-B2 | Fused heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-05-12 | — | — | US | disclosed |
| US-20130172292-A1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172292-A1 | FUSED HETEROCYCLIC COMPOUNDS | PDE10A, PDE3A, PDE2A | PRKDC 2651/4885PIK3CD 2669/4885ABL1 1397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.