Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 10/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL531228 | 0.82 | MEN1 (0.48) | TRPM8MEN1KMT2A | |
| SCHEMBL17965952 | 0.81 | PGR (0.57) | MEN1KMT2AMDM2 | |
| SCHEMBL531388 | 0.75 | KMT2A (0.49) | MEN1KMT2A | |
| SCHEMBL532486 | 0.75 | KMT2A (0.49) | MEN1KMT2A | |
| SCHEMBL19349131 | 0.73 | MEN1 (0.61) | MEN1KMT2A | |
| SCHEMBL15812249 | 0.72 | KMT2A (0.59) | MEN1KMT2A | |
| SCHEMBL15670744 | 0.72 | KMT2A (0.59) | MEN1KMT2A | |
| SCHEMBL838272 | 0.70 | MEN1 (0.57) | MEN1KMT2A | |
| SCHEMBL27171238 | 0.70 | MEN1 (0.57) | MEN1KMT2A | |
| SCHEMBL347067 | 0.70 | MEN1 (0.57) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7910592-B2 | CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-03-22 | — | — | US | disclosed |