Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131150 | 0.83 | BACE1 (0.35) | BACE1 | |
| SCHEMBL2084160 | 0.82 | BACE1 (0.43) | BACE1 | |
| SCHEMBL18765363 | 0.82 | BACE1 (0.38) | BACE1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2084416 | 0.82 | L3MBTL1 (0.42) | BACE1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2084811 | 0.80 | CHRM2 (0.41) | BACE1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL6751626 | 0.78 | TRIM24 (0.40) | BACE1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2084571 | 0.77 | BACE1 (0.40) | BACE1 | |
| SCHEMBL21379898 | 0.77 | MAPT (0.44) | BACE1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL30864849 | 0.77 | MAPT (0.44) | BACE1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5465604 | 0.76 | BACE1 (0.39) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797597-A1 | SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | Global Blood Therapeutics, Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| EP-2797416-A1 | SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | Global Blood Therapeutics, Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013102145-A1 | SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |
| WO-2013102142-A1 | SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |