Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TKT | P29401 | 3/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2084571 | 0.82 | BACE1 (0.40) | BACE1DCPS | |
| SCHEMBL18765363 | 0.81 | BACE1 (0.38) | BACE1DCPS | |
| SCHEMBL5719449 | 0.81 | BACE1 (0.39) | BACE1SMN1; SMN2MAPT | |
| SCHEMBL2063296 | 0.81 | FAAH (0.40) | BACE1HTTSMN1; SMN2KDM1AMAOB | |
| SCHEMBL3377814 | 0.80 | BACE1 (0.39) | BACE1KDM4EALDH1A1 | |
| SCHEMBL15389825 | 0.80 | BACE1 (0.42) | BACE1DCPS | |
| SCHEMBL5743431 | 0.79 | NOS2 (0.42) | BACE1NOS3NOS1NOS2DCPS | |
| SCHEMBL2598798 | 0.79 | LTA4H (0.41) | BACE1NOS3NOS1NOS2LTA4H | |
| SCHEMBL2084160 | 0.78 | BACE1 (0.43) | BACE1SMN1; SMN2TKTKDM4EALDH1A1 | |
| SCHEMBL21122006 | 0.78 | BACE1 (0.40) | BACE1HTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249620-A1 | Urea Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-10-25 | — | — | US | disclosed |
| EP-1764360-A1 | UREA DERIVATIVE | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | disclosed |
| EP-0453042-B1 | Novel 2,9-disubstituted-4H-pyrido-[1,2-a]pyrimidin-4-ones | JANSSEN PHARMACEUTICA NV (BE) | 1999-11-03 | — | — | EP | disclosed |
| US-5482943-A | ANTIPSYCHOTIC AGENTS, DOPAMINE ANTAGONIST | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-01-09 | — | — | US | disclosed |
| EP-0453042-A1 | Novel 2,9-disubstituted-4H-pyrido-[1,2-a]pyrimidin-4-ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-10-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249620-A1 | Urea Derivative | UGP2, SLC14A1, DGAT1 | BACE1 4411/4885NOS3 782/4885NOS1 1181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.