Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15084483 | 0.99 | MAPT (0.43) | MAPTUSP2KDM4EGAAHTT | |
| SCHEMBL17715015 | 0.93 | KDM4E (0.38) | MAPTUSP2KDM4EGAAHTT | |
| SCHEMBL15084465 | 0.88 | MAPT (0.45) | MAPTUSP2KDM4EGAAHTT | |
| SCHEMBL15067205 | 0.83 | ACHE (0.34) | MAPTUSP2KDM4EGAAHTT | |
| SCHEMBL15069634 | 0.79 | HSD17B10 (0.44) | MAPTUSP2KDM4ETP53HSD17B10 | |
| SCHEMBL15067435 | 0.78 | KDM4E (0.52) | MAPTUSP2KDM4EGAAHTT | |
| SCHEMBL17715020 | 0.77 | GFER (0.43) | MAPTUSP2KDM4ETP53HSD17B10 | |
| SCHEMBL15069374 | 0.77 | SLC6A5 (0.47) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6922067 | 0.76 | USP2 (0.43) | MAPTUSP2KDM4EGAAHTT | |
| SCHEMBL6922902 | 0.73 | GAA (0.40) | MAPTUSP2KDM4EGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797919-B1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE LTD (KY) | 2017-03-29 | — | — | EP | disclosed |
| US-9328111-B2 | Substituted cycloocta[5,6]pyrido[4,3,2-de]phthalazines as PARP inhibitors | BEIGENE LTD. (KY) | 2016-05-03 | — | — | US | disclosed |
| EP-2797919-A1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BeiGene, Ltd. (KY) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013097226-A1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE, LTD. (KY) | 2013-07-04 | — | — | WO | disclosed |