SCHEMBL1506869

SCHEMBL1506869

O=C1N=CC=C2C1=Cc1ccccc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.35
CDC25B P30305 2/20 0.33
CDC25A P30304 1/20 0.33
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
BCHE P06276 1/20 0.31
POLB P06746 1/20 0.31
PTPRC P08575 1/20 0.31
MAPT P10636 1/20 0.31
THRB P10828 1/20 0.31
PKM P14618 1/20 0.31
IDO1 P14902 1/20 0.31
HPGD P15428 1/20 0.31
ALOX15 P16050 1/20 0.31
PTPN1 P18031 1/20 0.31
ACHE P22303 1/20 0.31
CES1 P23141 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7786853 0.89 CDC25B (0.39) ABCG2CDC25BCDC25AMEN1KMT2A
SCHEMBL28494770 0.89 POLB (0.33) ABCG2KDM4EALDH1A1POLBMAPT
SCHEMBL29372537 0.75 ABCG2 (0.31) ABCG2
SCHEMBL1899000 0.75 ABCG2 (0.31) ABCG2
SCHEMBL30851365 0.74 TDP2 (0.36) CDC25BMEN1KMT2AKDM4EPTPRC
Hydrochloric Acid SCHEMBL7340963 0.73 ABCG2 (0.30) ABCG2
SCHEMBL4528417 0.70 CDC25B (0.33) ABCG2CDC25BCDC25AMEN1KMT2A
SCHEMBL10354666 0.70 ABCG2 (0.39) ABCG2CDC25BCDC25AMEN1KMT2A
SCHEMBL5886591 0.70 ABCG2 (0.39) ABCG2CDC25BCDC25AMEN1KMT2A
SCHEMBL9303135 0.69 CDC25A (0.36) ABCG2CDC25BCDC25AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110317172-B Azafluorenone derivative and preparation method and application thereof 广东工业大学 2020-11-10 CN claimed
CN-105924450-B Synthesis method of azafluorene spiro-aromatic hydrocarbon 南京邮电大学 2020-05-15 CN claimed
US-8702815-B2 Cyanoborate, fluoroalkylphosphate, fluoroalkylborate or imide dyes MERCK PATENT GMBH (DE) 2014-04-22 US claimed
EP-2292700-B1 Cyanoborate dyes MERCK PATENT GMBH (DE) 2011-11-02 EP claimed
US-20110190480-A1 CYANOBORATE, FLUOROALKYLPHOSPHATE, FLUOROALKYLBORATE OR IMIDE DYES IGNATYEV NIKOLAI MYKOLA 2011-08-04 US claimed
EP-1660591-B1 CATIONIC FLUOROALKYL-PHOSPHATE DYES MERCK PATENT GMBH (DE) 2010-10-27 EP claimed
US-20080275224-A1 Cyanoborate, Fluoroalkylphosphate, Fluoroalkylborate or Imide Dyes MERCK PATENT GMBH (DE) 2008-11-06 US claimed
EP-1198457-B1 QUATERNIZED AZAFLUORENONES AND THEIR USE IN AGENTS FOR DYING FIBERS CONTAINING KERATIN HENKEL KGAA (DE) 2005-12-14 EP claimed
WO-1994009002-A1 2-(AZA-9-FLUORENONYL)CARBAPENEM ANTIBACTERIAL AGENTS MERCK & CO., INC. (US) 1994-04-28 WO claimed
US-5294610-A Staphylococcus; side effect reduction MERCK & CO. INC. (US) 1994-03-15 US claimed
JP-9012555-A None JP disclosed
JP-8151370-A None JP disclosed
US-6444385-B1 None US disclosed
CN-117720575-B Hole transport material and preparation method and application thereof 深圳普太科技有限公司 2024-11-12 CN disclosed
CN-117720575-A Hole transport material and preparation method and application thereof 深圳普太科技有限公司 2024-03-19 CN disclosed
EP-0311010-A2 Alpha,Alpha-disubstituted aromatics and heteroaromatics as cognition enhancers THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1989-04-12 EP disclosed
US-4740602-A Indole derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1988-04-26 US disclosed
EP-0206225-A2 Indole derivatives MERCK PATENT GmbH (DE) 1986-12-30 EP disclosed
US-4537892-A ANTIDIABETIC AGENTS ALCON LABORATORIES, INC. (US) 1985-08-27 US disclosed
EP-0137333-A2 Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase ALCON LABORATORIES, INC. (US) 1985-04-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110190480-A1 CYANOBORATE, FLUOROALKYLPHOSPHATE, FLUOROALKYLBORATE OR IMIDE DYES ZAP70, MYLK3, KIT ABCG2 3524/4885CDC25B 1151/4885CDC25A 1419/4885
US-20080275224-A1 Cyanoborate, Fluoroalkylphosphate, Fluoroalkylborate or Imide Dyes ZAP70, MYLK3, KIT ABCG2 3524/4885CDC25B 1151/4885CDC25A 1419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.