Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420633 | 0.94 | NR1H2 (0.49) | ALDH1A1KMT2AHPGDNR1H2CYP2D6 | |
| SCHEMBL15069002 | 0.88 | NR1H2 (0.61) | ALDH1A1KMT2AHPGDNR1H2CYP2D6 | |
| SCHEMBL15688039 | 0.85 | LMNA (0.50) | ALDH1A1KMT2ANR1H2NPSR1KCNJ1 | |
| SCHEMBL588829 | 0.84 | NR1H2 (0.62) | ALDH1A1NR1H2LMNASMN1; SMN2CTSB | |
| SCHEMBL15690078 | 0.84 | ALDH1A1 (0.58) | ALDH1A1NR1H2L3MBTL1NPSR1KCNJ1 | |
| SCHEMBL29618194 | 0.83 | ALDH1A1 (0.49) | ALDH1A1KMT2AMAPTMEN1LMNA | |
| SCHEMBL588926 | 0.83 | ALDH1A1 (0.49) | ALDH1A1KMT2AMAPTMEN1LMNA | |
| SCHEMBL15687902 | 0.82 | MEN1 (0.48) | ALDH1A1KMT2ANR1H2KCNJ1MEN1 | |
| SCHEMBL31391167 | 0.81 | NR1H2 (0.48) | ALDH1A1NR1H2KCNJ1LMNASMN1; SMN2 | |
| SCHEMBL29958940 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KMT2ANR1H2MAPTKCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797927-A1 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES | Hanmi Pharm. Co., Ltd. (KR) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013100632-A1 | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES | HANMI PHARM CO., LTD. (KR) | 2013-07-04 | — | — | WO | disclosed |