Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61455 | 0.98 | MAPT (0.61) | MAPTKDM4ELMNACYP2D6TSHR | |
| Iodide SCHEMBL56400 | 0.96 | MAPT (0.64) | MAPTKDM4ELMNACYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL4613795 | 0.96 | MAPT (0.59) | MAPTKDM4ELMNACYP2D6TSHR | |
| SCHEMBL10600455 | 0.91 | MAPT (0.54) | MAPTKDM4ELMNACYP2D6TSHR | |
| SCHEMBL10600452 | 0.88 | MAPT (0.51) | MAPTKDM4ELMNACYP2D6TSHR | |
| SCHEMBL1871256 | 0.85 | MAPT (0.49) | MAPTKDM4ELMNACYP2D6TSHR | |
| P-Cresol SCHEMBL10512727 | 0.85 | MAPT (0.56) | MAPTKDM4ELMNACYP2D6TSHR | |
| Bromide SCHEMBL8009452 | 0.85 | CYP2D6 (0.62) | MAPTKDM4ELMNACYP2D6TSHR | |
| SCHEMBL4615373 | 0.84 | MAPT (0.64) | MAPTKDM4ELMNACYP2D6TSHR | |
| SCHEMBL1871259 | 0.84 | MAPT (0.48) | MAPTKDM4ELMNACYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699427-B1 | AGENT AND METHOD FOR OXIDATIVELY DYING KERATIN FIBERS | WELLA AG (DE) | 2008-02-27 | — | — | EP | claimed |
| US-7244278-B2 | Agent and method for oxidative coloring of keratin fibers | WELLA AG (DE) | 2007-07-17 | — | — | US | claimed |
| US-20070067927-A1 | Agent and method for oxidative coloring of keratin fibers | HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) | 2007-03-29 | — | — | US | claimed |
| US-20150353515-A1 | Novel analogs of resveratrol | HUANG WEN-HSIN (TW) | 2015-12-10 | — | — | US | disclosed |
| US-8702815-B2 | Cyanoborate, fluoroalkylphosphate, fluoroalkylborate or imide dyes | MERCK PATENT GMBH (DE) | 2014-04-22 | — | — | US | disclosed |
| EP-2292700-B1 | Cyanoborate dyes | MERCK PATENT GMBH (DE) | 2011-11-02 | — | — | EP | disclosed |
| US-20110190480-A1 | CYANOBORATE, FLUOROALKYLPHOSPHATE, FLUOROALKYLBORATE OR IMIDE DYES | IGNATYEV NIKOLAI MYKOLA | 2011-08-04 | — | — | US | disclosed |
| US-7939644-B2 | cationic dyes used for coloring plastics, fibers, leather and paper, for the preparation of flexographic printing inks, as ball-point pen pastes, as stamp inks, for use in data acquisition systems, reprography, in ink microfilters, in photogalvanics, laser technology and the photo industry | MERCK PATENT GMBH (DE) | 2011-05-10 | — | — | US | disclosed |
| EP-2292700-A1 | Cyanoborate dyes | Merck Patent GmbH (DE) | 2011-03-09 | — | — | EP | disclosed |
| US-20080275224-A1 | Cyanoborate, Fluoroalkylphosphate, Fluoroalkylborate or Imide Dyes | MERCK PATENT GMBH (DE) | 2008-11-06 | — | — | US | disclosed |
| US-7244278-B2 | Agent and method for oxidative coloring of keratin fibers | WELLA AG (DE) | 2007-07-17 | — | — | US | disclosed |
| US-20070067927-A1 | Agent and method for oxidative coloring of keratin fibers | HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) | 2007-03-29 | — | — | US | disclosed |
| EP-1660591-A1 | CYANOBORATE, FLUOROALKYL PHOSPHATE, FLUOROALKYL BORATE OR IMIDE DYES | MERCK PATENT GmbH (DE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005021661-A1 | CYANOBORATE, FLUOROALKYL PHOSPHATE, FLUOROALKYL BORATE OR IMIDE DYES | MERCK PATENT GMBH (DE) | 2005-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190480-A1 | CYANOBORATE, FLUOROALKYLPHOSPHATE, FLUOROALKYLBORATE OR IMIDE DYES | ZAP70, MYLK3, KIT | MAPT 3351/4885KDM4E 71/4885LMNA 871/4885 |
| US-20080275224-A1 | Cyanoborate, Fluoroalkylphosphate, Fluoroalkylborate or Imide Dyes | ZAP70, MYLK3, KIT | MAPT 3351/4885KDM4E 71/4885LMNA 871/4885 |
| US-20070067927-A1 | Agent and method for oxidative coloring of keratin fibers | KRT18, KIT, AOC1 | MAPT 1792/4885KDM4E 1510/4885LMNA 90/4885 |
| US-20150353515-A1 | Novel analogs of resveratrol | KDR, FLT1, SIRT1 | MAPT 1041/4885KDM4E 714/4885LMNA 3552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.