Sugi Predict

Sugi Predict / Compounds / SCHEMBL15069700

SCHEMBL15069700

SCHEMBL15069700

CCOC(=O)c1cc2c(-c3cc([N+](=O)[O-])ccc3F)cn(C)c(=O)c2n1Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ AR P10275 3/20 0.46
▸ KMT2A Q03164 4/20 0.41
▸ MEN1 O00255 3/20 0.41
▸ POLB P06746 3/20 0.41
▸ PLA2G2A P14555 1/20 0.41
▸ GNRHR P30968 1/20 0.40
▸ ALDH1A1 P00352 3/20 0.40
▸ MAPT P10636 2/20 0.40
▸ TSHR P16473 1/20 0.40
▸ ATM Q13315 1/20 0.40
▸ TDP1 Q9NUW8 1/20 0.40
▸ LMNA P02545 3/20 0.39
▸ BRD4 O60885 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ ELANE P08246 1/20 0.39
▸ CFTR P13569 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15069496 0.88 BRD4 (0.54) ARKMT2AMEN1POLBPLA2G2A
SCHEMBL15069505 0.86 MEN1 (0.41) KMT2AMEN1POLBALDH1A1MAPT
SCHEMBL15069638 0.78 BRD4 (0.58) ARBRD4
SCHEMBL17492522 0.77 P2RX3 (0.46) KMT2APOLBALDH1A1MAPTTSHR
SCHEMBL15069182 0.77 MAPT (0.49) KMT2AMEN1POLBALDH1A1MAPT
SCHEMBL15069340 0.76 BRD4 (0.51) BRD4
SCHEMBL15069695 0.76 BRD4 (0.54) BRD4
SCHEMBL15069166 0.74 BRD4 (0.63) KMT2APOLBALDH1A1MAPTTSHR
SCHEMBL15069533 0.73 MAPT (0.44) ARKMT2AMEN1POLBALDH1A1
SCHEMBL30824803 0.73 BRD4 (0.64) ALDH1A1MAPTLMNABRD4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230158039-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2023-05-25 — — US disclosed
US-20210236508-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2021-08-05 — — US disclosed
CN-106986872-B Bromodomain inhibitors 艾伯维公司 2020-04-21 — — CN disclosed
US-20180296566-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2018-10-18 — — US disclosed
EP-2797918-B1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2017-11-29 — — EP disclosed
US-20160143916-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2016-05-26 — — US disclosed
US-9296741-B2 Bromodomain inhibitors ABBVIE INC. (US) 2016-03-29 — — US disclosed
EP-2797918-A1 BROMODOMAIN INHIBITORS AbbVie Inc. (US) 2014-11-05 — — EP disclosed
US-20140162971-A1 BROMODOMAIN INHIBITORS ABBVIE INC. 2014-06-12 — — US disclosed
WO-2013097601-A1 BROMODOMAIN INHIBITORS ABBVIE INC. (US) 2013-07-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180296566-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 AR 400/4885KMT2A 405/4885MEN1 516/4885
US-20140162971-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 AR 400/4885KMT2A 405/4885MEN1 516/4885
US-20230158039-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 AR 400/4885KMT2A 405/4885MEN1 516/4885
US-20160143916-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 AR 400/4885KMT2A 405/4885MEN1 516/4885
US-20210236508-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 AR 400/4885KMT2A 405/4885MEN1 516/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.