Sugi Predict

Sugi Predict / Compounds / SCHEMBL15069182

SCHEMBL15069182

SCHEMBL15069182

CCOC(=O)c1cc2c(Br)cn(C)c(=O)c2n1Cc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.49
▸ ALDH1A1 P00352 5/20 0.49
▸ TDP1 Q9NUW8 4/20 0.49
▸ TSHR P16473 2/20 0.49
▸ POLB P06746 2/20 0.49
▸ ATM Q13315 1/20 0.49
▸ NOD2 Q9HC29 1/20 0.46
▸ NOD1 Q9Y239 1/20 0.46
▸ KDM4E B2RXH2 6/20 0.44
▸ MAPK1 P28482 3/20 0.44
▸ NPSR1 Q6W5P4 2/20 0.44
▸ LMNA P02545 2/20 0.43
▸ GAA P10253 1/20 0.43
▸ PKM P14618 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ TDP2 O95551 1/20 0.43
▸ NSD2 O96028 1/20 0.43
▸ PLCG1 P19174 1/20 0.43
▸ PAX8 Q06710 1/20 0.43
▸ KMT2A Q03164 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28388312 0.82 GAA (0.40) MAPTALDH1A1TDP1TSHRPOLB
SCHEMBL15069533 0.81 MAPT (0.44) MAPTALDH1A1TDP1TSHRPOLB
SCHEMBL15068036 0.81 ALDH1A1 (0.49) MAPTALDH1A1TDP1TSHRPOLB
SCHEMBL17492522 0.78 P2RX3 (0.46) MAPTALDH1A1TDP1TSHRPOLB
SCHEMBL15069166 0.77 BRD4 (0.63) MAPTALDH1A1TDP1TSHRPOLB
SCHEMBL15069505 0.77 MEN1 (0.41) MAPTALDH1A1TDP1TSHRPOLB
SCHEMBL15069594 0.77 ALDH1A1 (0.47) MAPTALDH1A1TDP1TSHRPOLB
SCHEMBL15069700 0.77 AR (0.46) MAPTALDH1A1TDP1TSHRPOLB
SCHEMBL3296461 0.77 NOD2 (0.59) MAPTALDH1A1TDP1TSHRPOLB
SCHEMBL24398095 0.76 TNF (0.38) MAPTALDH1A1ATMKDM4ENPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230158039-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2023-05-25 — — US disclosed
US-20210236508-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2021-08-05 — — US disclosed
US-20210070756-A1 TETRACYCLIC BROMODOMAIN INHIBITORS ABBVIE INC (US) 2021-03-11 — — US disclosed
US-20200291027-A1 TETRACYCLIC BROMODOMAIN INHIBITORS ABBVIE INC (US) 2020-09-17 — — US disclosed
CN-106986872-B Bromodomain inhibitors 艾伯维公司 2020-04-21 — — CN disclosed
EP-3539962-A1 TETRACYCLIC BROMODOMAIN INHIBITORS AbbVie Inc. (US) 2019-09-18 — — EP disclosed
EP-2970330-B1 TETRACYCLIC BROMODOMAIN INHIBITORS ABBVIE INC (US) 2019-04-17 — — EP disclosed
US-20180298003-A1 TETRACYCLIC BROMODOMAIN INHIBITORS ABBVIE INC (US) 2018-10-18 — — US disclosed
US-20180296566-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2018-10-18 — — US disclosed
US-10035800-B2 Substituted 1,4,10-triazadibenzo[cd,f]azulenes, substituted 1,4,5,10-tetraazadibenzo[cd,f]azulenes and substituted 1,4,5,7,10-pentaazadibenzo[cd,f]azulenes as bromodomain inhibitors ABBVIE INC. (US) 2018-07-31 — — US disclosed
EP-2797918-B1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2017-11-29 — — EP disclosed
US-20160143916-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2016-05-26 — — US disclosed
US-9296741-B2 Bromodomain inhibitors ABBVIE INC. (US) 2016-03-29 — — US disclosed
US-20160039821-A1 TETRACYCLIC BROMODOMAIN INHIBITORS ABBVIE INC. 2016-02-11 — — US disclosed
EP-2797918-A1 BROMODOMAIN INHIBITORS AbbVie Inc. (US) 2014-11-05 — — EP disclosed
US-20140162971-A1 BROMODOMAIN INHIBITORS ABBVIE INC. 2014-06-12 — — US disclosed
WO-2013097601-A1 BROMODOMAIN INHIBITORS ABBVIE INC. (US) 2013-07-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180296566-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 MAPT 2252/4885ALDH1A1 1794/4885TDP1 478/4885
US-10035800-B2 Substituted 1,4,10-triazadibenzo[cd,f]azulenes, substituted 1,4,5,10-tetraazadibenzo[cd,f]azulenes and substituted 1,4,5,7,10-pentaazadibenzo[cd,f]azulenes as bromodomain inhibitors BRD1, BRD3, BRD4 MAPT 3305/4885ALDH1A1 332/4885TDP1 1700/4885
US-20180298003-A1 TETRACYCLIC BROMODOMAIN INHIBITORS BRD3, BRD4, BRD1 MAPT 1302/4885ALDH1A1 2163/4885TDP1 729/4885
US-20200291027-A1 TETRACYCLIC BROMODOMAIN INHIBITORS BRD3, BRD4, BRD1 MAPT 1302/4885ALDH1A1 2163/4885TDP1 729/4885
US-20210070756-A1 TETRACYCLIC BROMODOMAIN INHIBITORS BRD3, BRD4, BRD1 MAPT 1302/4885ALDH1A1 2163/4885TDP1 729/4885
US-20140162971-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 MAPT 2252/4885ALDH1A1 1794/4885TDP1 478/4885
US-20160039821-A1 TETRACYCLIC BROMODOMAIN INHIBITORS BRD3, BRD4, BRD1 MAPT 1294/4885ALDH1A1 2065/4885TDP1 640/4885
US-20230158039-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 MAPT 2252/4885ALDH1A1 1794/4885TDP1 478/4885
US-20160143916-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 MAPT 2252/4885ALDH1A1 1794/4885TDP1 478/4885
US-20210236508-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 MAPT 2252/4885ALDH1A1 1794/4885TDP1 478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.