Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677466 | 0.93 | MAPK1 (0.75) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL15070209 | 0.90 | MAPK1 (0.67) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL15076914 | 0.89 | ALDH1A1 (0.89) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL15076916 | 0.86 | ALDH1A1 (0.80) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL15070383 | 0.86 | ALDH1A1 (0.88) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL6681044 | 0.83 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL15072200 | 0.82 | ALDH1A1 (0.67) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL15072193 | 0.81 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL15072201 | 0.81 | ALDH1A1 (0.66) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL15072197 | 0.81 | ALDH1A1 (0.66) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | PIK3R5, PIK3R4, PIK3C2B | ALDH1A1 3473/4885L3MBTL1 196/4885SMN1; SMN2 3990/4885 |
| US-20130165464-A1 | HETEROARYLS AND USES THEREOF | PIK3C2B, PI4KB, PIK3R4 | ALDH1A1 2884/4885L3MBTL1 866/4885SMN1; SMN2 3783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.