Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15070209 | 0.94 | MAPK1 (0.67) | MAPK1ALDH1A1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL15070211 | 0.93 | ALDH1A1 (0.71) | MAPK1ALDH1A1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL4501557 | 0.87 | ALDH1A1 (0.82) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL15076916 | 0.85 | ALDH1A1 (0.80) | MAPK1ALDH1A1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL15076914 | 0.84 | ALDH1A1 (0.89) | MAPK1ALDH1A1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL6681044 | 0.84 | ALDH1A1 (1.00) | MAPK1ALDH1A1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL28771391 | 0.84 | ALDH1A1 (0.78) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL6679218 | 0.83 | MAPK1 (0.64) | MAPK1ALDH1A1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL10144728 | 0.80 | MAPK1 (0.72) | MAPK1ALDH1A1L3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL11156647 | 0.80 | ALDH1A1 (0.78) | MAPK1ALDH1A1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004043951-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | CAREX S.A. (FR) | 2004-05-27 | — | — | WO | claimed |
| US-20120302581-A1 | Methods and Compositions for the Treatment of RAS Associated Disorders | THE TRUSTEES OF DARTMOUTH COLLEGE | 2012-11-29 | — | — | US | disclosed |
| US-20120302581-A1 | Methods and Compositions for the Treatment of RAS Associated Disorders | THE TRUSTEES OF DARTMOUTH COLLEGE | 2012-11-29 | — | — | US | disclosed |
| WO-2004043951-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | CAREX S.A. (FR) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302581-A1 | Methods and Compositions for the Treatment of RAS Associated Disorders | NRAS, HRAS, KRAS | MAPK1 557/4885ALDH1A1 3966/4885L3MBTL1 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.