Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1535312 | 0.84 | FAAH (0.60) | FAAHKCNH2CNR1CNR2GPR55 | |
| SCHEMBL1959216 | 0.84 | FAAH (0.62) | FAAHKCNH2PTGS2CCNE1CDK2 | |
| SCHEMBL7992233 | 0.84 | FAAH (0.62) | FAAHKCNH2PTGS2CCNE1CDK2 | |
| SCHEMBL1962075 | 0.81 | FAAH (0.52) | FAAHKCNH2KDM4EDRD2AURKA | |
| SCHEMBL1964011 | 0.81 | FAAH (0.64) | FAAHKCNH2CNR1CNR2GPR55 | |
| SCHEMBL1535225 | 0.79 | FAAH (0.59) | FAAHKCNH2CNR1CNR2GPR55 | |
| SCHEMBL7992508 | 0.79 | FAAH (0.71) | FAAHKCNH2CNR1CNR2GPR55 | |
| SCHEMBL1535178 | 0.79 | FAAH (0.59) | FAAHKCNH2CDK2KDM4EDRD2 | |
| SCHEMBL1959577 | 0.78 | FAAH (0.56) | FAAHKCNH2CNR1CNR2GPR55 | |
| SCHEMBL1535165 | 0.78 | FAAH (0.61) | FAAHKCNH2PTGS2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165483-A1 | HETEROARYLS AND USES THEREOF | PIK3R5, PIK3R4, PIK3C2B | FAAH 2501/4885KCNH2 3671/4885CNR1 2278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.