Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1959216 | 0.88 | FAAH (0.62) | FAAHKCNH2PTGS2KDM4EDRD2 | |
| SCHEMBL1535312 | 0.86 | FAAH (0.60) | FAAHKCNH2PTGS2KDM4EDRD2 | |
| SCHEMBL15070809 | 0.84 | FAAH (0.60) | FAAHKCNH2PTGS2KDM4EDRD2 | |
| SCHEMBL1961515 | 0.81 | FAAH (0.68) | FAAHKCNH2PTGS2KDM4EDRD2 | |
| SCHEMBL1964011 | 0.81 | FAAH (0.64) | FAAHKCNH2PTGS2KDM4EDRD2 | |
| SCHEMBL1959185 | 0.79 | FAAH (0.59) | FAAHKCNH2PTGS2KDM4EDRD2 | |
| SCHEMBL1535165 | 0.78 | FAAH (0.61) | FAAHKCNH2PTGS2KDM4EDRD2 | |
| SCHEMBL1535159 | 0.78 | FAAH (0.61) | FAAHKCNH2PTGS2KDM4EDRD2 | |
| SCHEMBL1962085 | 0.78 | MEN1 (0.61) | FAAHKCNH2KDM4EDRD2MAPT | |
| SCHEMBL1960584 | 0.77 | FAAH (0.50) | FAAHKCNH2PTGS2KDM4EDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151991-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |