Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17453264 | 0.90 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL15072425 | 0.88 | PTGS2 (0.83) | PTGS2PTGS1 | |
| SCHEMBL3824189 | 0.88 | PTGS2 (0.73) | PTGS2PTGS1 | |
| SCHEMBL3826868 | 0.86 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL15072482 | 0.85 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL3824466 | 0.85 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL15051307 | 0.85 | PTGS2 (0.83) | PTGS2PTGS1 | |
| SCHEMBL462500 | 0.85 | PTGS2 (0.83) | PTGS2PTGS1 | |
| SCHEMBL3827980 | 0.84 | PTGS2 (0.72) | PTGS2PTGS1 | |
| SCHEMBL3824708 | 0.84 | PTGS2 (0.72) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9162979-B2 | 1,5-Diary1-2-alkylpyrrole-3-substituted nitro esters, selective COX-2 inhibitors and nitric oxide donors | ROTTAPHARM BIOTECH S.R.L. (IT) | 2015-10-20 | — | — | US | disclosed |
| US-20130165494-A1 | 1,5-Diaryl-2-alkylpyrrole-3-Substituted Nitro Esters, Selective COX-2 Inhibitors and Nitric Oxide Donors | ROTTAPHARM S.P.A. (IT) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165494-A1 | 1,5-Diaryl-2-alkylpyrrole-3-Substituted Nitro Esters, Selective COX-2 Inhibitors and Nitric Oxide Donors | NOS3, PTGER3, PTGES3 | PTGS2 9/4885PTGS1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.