Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.63 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.56 |
| ▸ | FBP1 | P09467 | 3/20 | 0.55 |
| ▸ | GAK | O14976 | 2/20 | 0.55 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507536 | 0.86 | EGFR (0.55) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1507649 | 0.84 | EGFR (0.64) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1507634 | 0.83 | FBP1 (0.65) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL1507704 | 0.82 | FBP1 (0.64) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1507694 | 0.80 | EGFR (0.57) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL1507568 | 0.78 | EGFR (0.69) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4354683 | 0.78 | EGFR (0.73) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8205256 | 0.78 | EGFR (0.91) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8213254 | 0.77 | EGFR (0.77) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL641749 | 0.77 | EGFR (1.00) | EGFRHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3103799-A1 | QUINAZOLINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2016-12-14 | — | — | EP | disclosed |
| EP-2163546-B1 | Quinazoline derivatives | PFIZER PROD INC (US) | 2016-06-01 | — | — | EP | disclosed |
| EP-2295415-A1 | Quinazoline derivatives | OSI Pharmaceuticals, Inc. (US) | 2011-03-16 | — | — | EP | disclosed |
| EP-2163546-A1 | Quinazoline derivatives | Pfizer Products Incorporated (US) | 2010-03-17 | — | — | EP | disclosed |
| EP-0817775-B1 | QUINAZOLINE DERIVATIVES | PFIZER (US) | 2001-09-12 | — | — | EP | disclosed |
| EP-1110953-A1 | Quinazoline derivatives | PFIZER INC. (US) | 2001-06-27 | — | — | EP | disclosed |