Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | TP53 | P04637 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15076397 | 0.96 | MAPT (0.55) | MAPTTP53LMNARAB9ASMN1; SMN2 | |
| SCHEMBL15076401 | 0.90 | MAPT (0.54) | MAPTTP53LMNARAB9ASMN1; SMN2 | |
| SCHEMBL15076476 | 0.88 | CYP3A4 (0.57) | MAPTTP53LMNARAB9ASMN1; SMN2 | |
| SCHEMBL15076713 | 0.88 | MAPT (0.60) | MAPTTP53LMNARAB9ASMN1; SMN2 | |
| SCHEMBL19157110 | 0.86 | MAPT (0.52) | MAPTTP53LMNARAB9ASMN1; SMN2 | |
| SCHEMBL15076402 | 0.86 | MAPT (0.54) | MAPTTP53LMNARAB9ASMN1; SMN2 | |
| SCHEMBL15277032 | 0.85 | MAPT (0.56) | MAPTTP53LMNARAB9ASMN1; SMN2 | |
| SCHEMBL15076768 | 0.85 | MAPT (0.60) | MAPTTP53LMNARAB9ASMN1; SMN2 | |
| SCHEMBL19324776 | 0.85 | MAPT (0.48) | MAPTTP53LMNARAB9ASMN1; SMN2 | |
| SCHEMBL15076488 | 0.84 | CYP3A4 (0.62) | MAPTTP53LMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10632112-B2 | Combination therapy for treatment of HBV infections | NOVIRA THERAPEUTICS, INC. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20190209541-A1 | COMBINATION THERAPY FOR TREATMENT OF HBV INFECTIONS | NOVIRA THERAPEUTICS INC. | 2019-07-11 | — | — | US | disclosed |
| US-10196376-B2 | Hepatitis B antiviral agents | NOVIRA THERAPEUTICS, INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170334882-A1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS, INC | 2017-11-23 | — | — | US | disclosed |
| US-20170334882-A1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS, INC | 2017-11-23 | — | — | US | disclosed |
| US-9751857-B2 | Hepatitis B antiviral agents | NOVIRA THERAPEUTICS, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-9751857-B2 | Hepatitis B antiviral agents | NOVIRA THERAPEUTICS, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| EP-2794565-B1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS INC (US) | 2017-07-26 | — | — | EP | disclosed |
| US-20170182021-A1 | COMBINATION THERAPY FOR TREATMENT OF HBV INFECTIONS | NOVIRA THERAPEUTICS, INC. | 2017-06-29 | — | — | US | disclosed |
| US-20170182021-A1 | COMBINATION THERAPY FOR TREATMENT OF HBV INFECTIONS | NOVIRA THERAPEUTICS, INC. | 2017-06-29 | — | — | US | disclosed |
| US-9061008-B2 | Hepatitis B antiviral agents | NOVIRA THERAPEUTICS, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20150152073-A1 | Hepatitis B Antiviral Agents | NOVIRA THERAPEUTICS, INC. | 2015-06-04 | — | — | US | disclosed |
| US-20150152073-A1 | Hepatitis B Antiviral Agents | NOVIRA THERAPEUTICS, INC. | 2015-06-04 | — | — | US | disclosed |
| US-20140178337-A1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS, INC. | 2014-06-26 | — | — | US | disclosed |
| US-20140178337-A1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS, INC. | 2014-06-26 | — | — | US | disclosed |
| US-8629274-B2 | Hepatitis B antiviral agents | NOVIRA THERAPEUTICS, INC. (US) | 2014-01-14 | — | — | US | disclosed |
| US-8629274-B2 | Hepatitis B antiviral agents | NOVIRA THERAPEUTICS, INC. (US) | 2014-01-14 | — | — | US | disclosed |
| US-20130251673-A1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-20130251673-A1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| WO-2013096744-A1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS, INC. (US) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10632112-B2 | Combination therapy for treatment of HBV infections | IFNAR1, IFNG, HDGF | MAPT 3999/4885TP53 920/4885LMNA 1365/4885 |
| US-20150152073-A1 | Hepatitis B Antiviral Agents | HAVCR2, EIF2AK2, IRF3 | MAPT 4607/4885TP53 1486/4885LMNA 3521/4885 |
| US-20140178337-A1 | HEPATITIS B ANTIVIRAL AGENTS | HAVCR2, EIF2AK2, IRF3 | MAPT 4607/4885TP53 1486/4885LMNA 3521/4885 |
| US-10196376-B2 | Hepatitis B antiviral agents | HAVCR2, EIF2AK2, IRF3 | MAPT 4607/4885TP53 1486/4885LMNA 3521/4885 |
| US-20190209541-A1 | COMBINATION THERAPY FOR TREATMENT OF HBV INFECTIONS | IFNAR1, IFNG, HDGF | MAPT 3999/4885TP53 920/4885LMNA 1365/4885 |
| US-20170334882-A1 | HEPATITIS B ANTIVIRAL AGENTS | HAVCR2, EIF2AK2, IRF3 | MAPT 4607/4885TP53 1486/4885LMNA 3521/4885 |
| US-20130251673-A1 | HEPATITIS B ANTIVIRAL AGENTS | HAVCR2, EIF2AK2, IRF3 | MAPT 4607/4885TP53 1486/4885LMNA 3521/4885 |
| US-20170182021-A1 | COMBINATION THERAPY FOR TREATMENT OF HBV INFECTIONS | IFNAR1, IFNG, HDGF | MAPT 3999/4885TP53 920/4885LMNA 1365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.