Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.61 |
| ▸ | IDO1 | P14902 | 1/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30301502 | 1.00 | DYRK1A (0.61) | DYRK1AIDO1PDPK1JAK2GSK3B | |
| SCHEMBL9436096 | 0.87 | PDPK1 (0.59) | DYRK1AIDO1PDPK1JAK2GSK3B | |
| SCHEMBL261067 | 0.85 | IDO1 (0.62) | DYRK1AIDO1PDPK1JAK2GSK3B | |
| SCHEMBL30075258 | 0.85 | IDO1 (0.62) | DYRK1AIDO1PDPK1JAK2GSK3B | |
| SCHEMBL19208914 | 0.83 | JAK2 (0.59) | DYRK1AIDO1PDPK1JAK2GSK3B | |
| SCHEMBL11970499 | 0.83 | JAK1 (0.54) | DYRK1AIDO1PDPK1JAK2GSK3B | |
| SCHEMBL21811353 | 0.83 | IDO1 (0.64) | DYRK1AIDO1PDPK1JAK2GSK3B | |
| SCHEMBL30258217 | 0.83 | KDM4E (0.63) | DYRK1AIDO1PDPK1JAK2GSK3B | |
| SCHEMBL29871192 | 0.83 | IDO1 (0.64) | DYRK1AIDO1PDPK1JAK2GSK3B | |
| SCHEMBL498163 | 0.83 | KDM4E (0.63) | DYRK1AIDO1PDPK1JAK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104098513-B | A kind of indazole compound derivative and preparation method thereof | 天津市斯芬克司药物研发有限公司 | 2016-08-24 | — | — | CN | claimed |
| WO-2023025109-A1 | TOLL-LIKE RECEPTOR INHIBITOR AND PREPARATION AND APPLICATION THEREOF | 上海维申医药有限公司 | 2023-03-02 | — | — | WO | disclosed |
| CN-104098513-B | A kind of indazole compound derivative and preparation method thereof | 天津市斯芬克司药物研发有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-104324026-B | A kind of pharmaceutical composition antianxity and application thereof | 温州医科大学 | 2016-08-24 | — | — | CN | disclosed |
| CN-104324026-A | Anti-anxiety pharmaceutical composition and application thereof | BAI LINGQIANG | 2015-02-04 | — | — | CN | disclosed |
| CN-104324026-A | Anti-anxiety pharmaceutical composition and application thereof | BAI LINGQIANG | 2015-02-04 | — | — | CN | disclosed |
| CN-104098513-A | Indazole compound derivative and preparation method | SPHINX SCIENT LAB CORP | 2014-10-15 | — | — | CN | disclosed |
| US-20130165440-A1 | JAK1 Inhibitors | EXELIXIS, INC. (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165440-A1 | JAK1 Inhibitors | JAK1, JAK2, JAK3 | DYRK1A 752/4885IDO1 160/4885PDPK1 783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.