Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.64 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.63 |
| ▸ | PAK1 | Q13153 | 5/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | JAK1 | P23458 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 4/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21811353 | 1.00 | IDO1 (0.64) | IDO1YTHDC1PAK1DYRK1AJAK2 | |
| SCHEMBL31182067 | 0.90 | IDO1 (0.60) | IDO1YTHDC1PAK1DYRK1AJAK2 | |
| SCHEMBL13386937 | 0.88 | YTHDC1 (0.63) | IDO1YTHDC1PAK1DYRK1AJAK2 | |
| SCHEMBL30301502 | 0.83 | DYRK1A (0.61) | IDO1YTHDC1PAK1DYRK1AJAK2 | |
| SCHEMBL15077318 | 0.83 | DYRK1A (0.61) | IDO1YTHDC1PAK1DYRK1AJAK2 | |
| SCHEMBL30258217 | 0.82 | KDM4E (0.63) | IDO1DYRK1AJAK2GSK3BPDPK1 | |
| SCHEMBL498163 | 0.82 | KDM4E (0.63) | IDO1DYRK1AJAK2GSK3BPDPK1 | |
| SCHEMBL261067 | 0.81 | IDO1 (0.62) | IDO1DYRK1AJAK2GSK3BPDPK1 | |
| SCHEMBL30075258 | 0.81 | IDO1 (0.62) | IDO1DYRK1AJAK2GSK3BPDPK1 | |
| SCHEMBL30912958 | 0.80 | IDO1 (0.77) | IDO1DYRK1AJAK2JAK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4037772-A1 | INDAZOLE CARBOXAMIDES AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2022-08-10 | — | — | EP | disclosed |