Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.43 |
| ▸ | CBS | P35520 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15077681 | 1.00 | ALDH1A1 (0.47) | ALDH1A1NPC1RAB9ALMNAMAOB | |
| SCHEMBL10054661 | 0.89 | ALDH1A1 (0.58) | ALDH1A1NPC1RAB9ALMNAMEN1 | |
| SCHEMBL30725970 | 0.89 | ALDH1A1 (0.58) | ALDH1A1NPC1RAB9ALMNAMEN1 | |
| SCHEMBL6324673 | 0.89 | ALDH1A1 (0.58) | ALDH1A1NPC1RAB9ALMNAMEN1 | |
| SCHEMBL30725971 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPTABCB1KDM4ECYP3A4 | |
| SCHEMBL2629461 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPTABCB1KDM4ECYP3A4 | |
| SCHEMBL30966448 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPTABCB1KDM4ECYP3A4 | |
| SCHEMBL29169330 | 0.80 | ALDH1A1 (0.63) | ALDH1A1ABCB1KDM4ECYP3A4HPGD | |
| SCHEMBL15373706 | 0.78 | KCNH2 (0.57) | ALDH1A1MAOBCYP19A1KCNH2TRPV1 | |
| SCHEMBL18104369 | 0.78 | ALDH1A1 (0.68) | ALDH1A1NPC1RAB9AMAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206100-B2 | Route to synthetic analogues of Rocaglamide and Aglafoline using cascade transformations initiated by oxy-cope rearrangement of bis-alkynes | The Florida State University Research Foundation, Inc. (US) | 2015-12-08 | — | — | US | disclosed |
| US-20130165683-A1 | NEW ROUTE TO SYNTHETIC ANALOGUES OF ROCAGLAMIDE AND AGLAFOLINE USING CASCADE TRANSFORMATIONS INITIATED BY OXY-COPE REARRANGEMENT OF BIS-ALKYNES | THE FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION INC. | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165683-A1 | NEW ROUTE TO SYNTHETIC ANALOGUES OF ROCAGLAMIDE AND AGLAFOLINE USING CASCADE TRANSFORMATIONS INITIATED BY OXY-COPE REARRANGEMENT OF BIS-ALKYNES | COASY, RIMKLA, ACSL3 | ALDH1A1 1262/4885NPC1 1681/4885RAB9A 1764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.