ACSL3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL24634565	1.00	1/20
SCHEMBL26780273	1.00	1/20
SCHEMBL27256174	0.81	1/20
SCHEMBL27256207	0.81	1/20
SCHEMBL24634626	0.74	1/20
SCHEMBL27256210	0.69	1/20
SCHEMBL9413588	0.60	1/20
SCHEMBL24634557	0.56	1/20
SCHEMBL1247012	0.56	1/20
SCHEMBL1794125	0.56	1/20
SCHEMBL1794127	0.56	1/20
SCHEMBL1794239	0.56	1/20
SCHEMBL10614660	0.55	1/20
SCHEMBL25524814	0.55	1/20
Trifluoroacetic Acid (SCHEMBL1794473)	0.55	1/20
Trifluoroacetic Acid (SCHEMBL1796405)	0.55	1/20
SCHEMBL28424879	0.55	1/20
SCHEMBL29972870	0.55	1/20
SCHEMBL1749499	0.55	1/20
SCHEMBL20594364	0.54	1/20

Clinical trials — most relevant to ACSL3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Fenofibrate Therapy in Diabetic Nephropathy	PHASE3	UNKNOWN
Comparison of Coenzyme A and Pantethine Capsule for Safety and Efficacy On Patients With Hyperlipidemia	PHASE3	COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease	PHASE2	COMPLETED
Effect of Insulin Lowering on Lipogenesis	PHASE1	RECRUITING
Liver Positron Emission Tomography (PET) Study of Non Alcoholic Fatty Liver Disease	EARLY_PHASE1	COMPLETED
Androgens and NAFLD Longitudinal Cohort Study	nan	RECRUITING
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Familial Partial Lipodystrophy Study	nan	COMPLETED
Use of MCT Oil for Enhancement of Weight Loss in Obese Patients	nan	COMPLETED
Frequency of Metabolic Dysfunction Associated Fatty Liver Disease in Patients With Acute Coronary Syndromes	nan	NOT_YET_RECRUITING
Fatty Acid Metabolism and Insulin Sensitivity: the Role of Endurance Exercise	nan	COMPLETED
Fatty Acid Oxidation Defects and Insulin Sensitivity	nan	COMPLETED
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study	nan	COMPLETED
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism	nan	RECRUITING
Effect of Dietary SFA and Fructose on Hepatic Insulin Sensitivity	nan	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
The Roles of SAH Gene Family in Athrogenic Dyslipidemia in Postmenopausal Women	nan	UNKNOWN
Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing	nan	COMPLETED
NASH AMPK Exercise Dosing (AMPED) Trial	nan	RECRUITING
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
Omega-3 vs Very Low Calorie Diet for Liver Size Reduction	nan	UNKNOWN
De Novo Lipogenesis in Severity of NAFLD	nan	COMPLETED
Promotion of Weight Management	nan	ACTIVE_NOT_RECRUITING
Hepatic Glycogen and Fat Oxidation	nan	COMPLETED
Role of Dairy Products in Weight Maintenance	nan	COMPLETED
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
Glycemic Index/Saturated Fatty Acid Diet and Hepatic Fat	nan	COMPLETED
De Novo Lipogenesis and Insulin Sensitivity in Obese	nan	COMPLETED
Gene Expression in Obesity and Insulin Resistance	nan	COMPLETED
Hepatic Energy Fluxes in NASH and NAS Patients	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ACSL3 binder may also engage these)

Protein	Name	Similarity
Q5R668	—	1.000	Q5R668 →
Q9CZW4	—	1.000	Q9CZW4 →
Q63151	—	1.000	Q63151 →
Q9QUJ7	—	1.000	Q9QUJ7 →
O35547	—	1.000	O35547 →
ACSL4	Long-chain-fatty-acid--CoA ligase 4	1.000	landscape →
Q9CAP8	—	0.996	Q9CAP8 →
Q8LKS5	—	0.993	Q8LKS5 →
P30624	—	0.992	P30624 →
M4ISH1	—	0.991	M4ISH1 →
Q2XU92	—	0.990	Q2XU92 →
Q8LPS1	—	0.990	Q8LPS1 →
Q9P7D7	—	0.990	Q9P7D7 →
Q5FVE4	—	0.990	Q5FVE4 →
Q9SJD4	—	0.990	Q9SJD4 →
Q55DR6	—	0.989	Q55DR6 →
Q9C7W4	—	0.989	Q9C7W4 →
Q9T009	—	0.988	Q9T009 →
O60135	—	0.988	O60135 →
O22898	—	0.987	O22898 →
Q9T0A0	—	0.986	Q9T0A0 →
O88813	—	0.985	O88813 →
O24146	—	0.985	O24146 →
Q8JZR0	—	0.985	Q8JZR0 →
P39002	—	0.984	P39002 →
ACSL5	Long-chain-fatty-acid--CoA ligase 5	0.984	landscape →
O24540	—	0.984	O24540 →
P31685	—	0.984	P31685 →
Q9XIA9	—	0.984	Q9XIA9 →
A1L1K7	—	0.983	A1L1K7 →