Etilefrine

Etilefrine

SCHEMBL150802

CCNCC(O)c1cccc(O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 3/20 1.00
LMNA P02545 3/20 1.00
GALR3 O60755 1/20 1.00
ADRB2 P07550 3/20 0.70
ADRB1 P08588 2/20 0.70
ADRA1A P35348 2/20 0.70
HTR1A P08908 1/20 0.70
ADRA2A P08913 1/20 0.70
ADRB3 P13945 1/20 0.70
TSHR P16473 1/20 0.70
ADRA2B P18089 1/20 0.70
ADRA2C P18825 1/20 0.70
NFKB1 P19838 1/20 0.70
DRD1 P21728 1/20 0.70
HTR7 P34969 1/20 0.70
ADRA1B P35368 1/20 0.70
DRD3 P35462 1/20 0.70
RAB9A P51151 1/20 0.70
SLC6A3 Q01959 1/20 0.70
KDM4E B2RXH2 2/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Etilefrine SCHEMBL30510958 1.00 HIF1A (1.00) HIF1ALMNAGALR3ADRB2ADRB1
Etilefrine SCHEMBL29603739 1.00 HIF1A (1.00) HIF1ALMNAGALR3ADRB2ADRB1
Etilefrine SCHEMBL31204243 0.98 HIF1A (0.97) HIF1ALMNAGALR3ADRB2ADRB1
Etilefrine SCHEMBL207591 0.98 HIF1A (0.97) HIF1ALMNAGALR3ADRB2ADRB1
Etilefrine SCHEMBL10753730 0.89 HIF1A (0.78) HIF1ALMNAGALR3ADRB2ADRB1
Etilefrine SCHEMBL2733170 0.89 HIF1A (0.78) HIF1ALMNAGALR3ADRB2ADRB1
Etilefrine SCHEMBL5488709 0.89 HIF1A (0.78) HIF1ALMNAGALR3ADRB2ADRB1
SCHEMBL19329764 0.84 HIF1A (0.72) HIF1ALMNAGALR3ADRB2ADRB1
SCHEMBL16709940 0.83 LMNA (0.71) HIF1ALMNAGALR3ADRB2ADRB1
Phenylephrine SCHEMBL4711 0.82 HIF1A (1.00) HIF1ALMNAGALR3ADRB2ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2423 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4704839-A2 IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF ALPHERABIO LLC (US) 2026-03-11 EP claimed
WO-2025265094-A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-12-26 WO claimed
EP-4599048-A1 COMPOSITIONS AND METHODS FOR SMALL MOLECULE BASED EXPANSION OF PLURIPOTENT STEM CELLS Trailhead Biosystems Inc. (US) 2025-08-13 EP claimed
US-20250213647-A1 CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE UNIVERSITY OF SOUTH FLORIDA 2025-07-03 US claimed
EP-4569090-A2 METHODS AND COMPOSITIONS FOR GENERATING OLIGODENDROCYTE PROGENITOR CELLS Trailhead Biosystems Inc. (US) 2025-06-18 EP claimed
US-20250108056-A1 SUBLINGUAL FORMULATION FOR HYPOTENSION AND SYNCOPE HAMDAN MOHAMED HUSSEIN (US) 2025-04-03 US claimed
US-20240398729-A1 Methods and Compositions for the Treatment of Cytoplasmic Glycogen Storage Disorders DUKE UNIVERSITY (US) 2024-12-05 US claimed
EP-4157451-B1 SUBLINGUAL FORMULATION FOR HYPOTENSION AND SYNCOPE HAMDAN MOHAMED HUSSEIN (US) 2024-12-04 EP claimed
WO-2024226608-A2 IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF AGLAEAPHARMA INC. (US) 2024-10-31 WO claimed
US-20240316057-A1 PULSATILE RELEASE CAFFEINE FORMULATION GALVENTA AG (TR) 2024-09-26 US claimed
WO-1997037629-A1 PROCESS FOR ENCAPSULATION OF CAPLETS IN A CAPSULE AND SOLID DOSAGE FORMS OBTAINABLE BY SUCH PROCESS WARNER-LAMBERT COMPANY (US) 1997-10-16 WO claimed
EP-0797424-A1 PROCESS FOR ENCAPSULATION OF CAPLETS IN A CAPSULE AND SOLID DOSAGE FORMS OBTAINABLE BY SUCH PROCESS WARNER-LAMBERT COMPANY (US) 1997-10-01 EP claimed
WO-1996018370-A1 PROCESS FOR ENCAPSULATION OF CAPLETS IN A CAPSULE AND SOLID DOSAGE FORMS OBTAINABLE BY SUCH PROCESS WARNER-LAMBERT COMPANY (US) 1996-06-20 WO claimed
WO-1995032981-A1 NOVEL GLYCOSIDE COMPOUNDS AND PRODUCTION AND USE THEREOF HARRIER, INC. (US) 1995-12-07 WO claimed
EP-0480934-B1 A SLIMMING PHARMACEUTICAL COMPOSITION NYCOMED DAK AS (DK) 1994-06-29 EP claimed
EP-0480934-A1 A SLIMMING PHARMACEUTICAL COMPOSITION. DAK LAB AS (DK) 1992-04-22 EP claimed
WO-1991000730-A1 A SLIMMING PHARMACEUTICAL COMPOSITION DAK-LABORATORIET A/S (DK) 1991-01-24 WO claimed
EP-0213108-A2 Pharmaceutical preparation containing an antihypotonic as the active agent Burghart, Kurt, Dr. (DE) 1987-03-04 EP claimed
EP-0162320-A1 Use of etilefrine or of pivalate of etilefrine in the preparation of a drug for the prolonged treatment of disturbances of the blood supply not caused by hypertension Klinge Pharma GmbH (DE) 1985-11-27 EP claimed
EP-0152379-A2 Process for preparing pharmaceutical compositions containing unilamellar liposomes CIBA-GEIGY AG (CH) 1985-08-21 EP claimed