Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12203461 | 0.88 | BRD4 (0.36) | HTR7BRD4HTR1APRMT5WDR77 | |
| SCHEMBL7916585 | 0.86 | TAAR1 (0.42) | HTR7BRD4HTR1APRMT5WDR77 | |
| SCHEMBL15080294 | 0.81 | OTUD7B (0.38) | BRD4PIK3CDPIK3CG | |
| SCHEMBL15080312 | 0.78 | CYP3A4 (0.36) | BACE1 | |
| SCHEMBL7928716 | 0.77 | BRD4 (0.37) | HTR7BRD4HTR1APRMT5WDR77 | |
| SCHEMBL15080311 | 0.77 | BACE1 (0.40) | BACE1 | |
| SCHEMBL7922955 | 0.76 | PRMT5 (0.36) | HTR7BRD4HTR1APRMT5WDR77 | |
| SCHEMBL7930498 | 0.71 | PIK3CD (0.40) | HTR7BRD4HTR1APRMT5WDR77 | |
| SCHEMBL12203463 | 0.68 | OTUD7B (0.40) | BRD4PIK3CDPIK3CG | |
| SCHEMBL7924981 | 0.67 | BRD4 (0.47) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476274-B2 | Biaryl spiroaminooxazoline analogues as Alpha2C adrenergic receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2013-07-02 | — | — | US | disclosed |