Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12203463 | 0.87 | OTUD7B (0.40) | OTUD7BBRD4ABL1CHEK1AKT2 | |
| SCHEMBL7916587 | 0.85 | TAAR1 (0.42) | OTUD7BBRD4ABL1CHEK1AKT2 | |
| SCHEMBL7924966 | 0.85 | TAAR1 (0.42) | OTUD7BBRD4ABL1CHEK1AKT2 | |
| SCHEMBL7916591 | 0.85 | TAAR1 (0.42) | OTUD7BBRD4ABL1CHEK1AKT2 | |
| SCHEMBL12203567 | 0.83 | OTUD7B (0.40) | OTUD7BBRD4ABL1CHEK1AKT2 | |
| SCHEMBL7923477 | 0.81 | TAAR1 (0.42) | OTUD7BBRD4ABL1CHEK1AKT2 | |
| SCHEMBL15080293 | 0.81 | HTR7 (0.35) | BRD4PIK3CDPIK3CG | |
| SCHEMBL15080312 | 0.78 | CYP3A4 (0.36) | — | |
| SCHEMBL15080311 | 0.78 | BACE1 (0.40) | — | |
| SCHEMBL7928718 | 0.76 | OTUD7B (0.39) | OTUD7BBRD4ABL1CHEK1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476274-B2 | Biaryl spiroaminooxazoline analogues as Alpha2C adrenergic receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2013-07-02 | — | — | US | disclosed |