Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947093 | 0.89 | MEN1 (0.53) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL12800176 | 0.84 | ADRB2 (0.39) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL13662109 | 0.80 | MEN1 (0.56) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL9386347 | 0.79 | MEN1 (0.47) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL11991390 | 0.76 | MEN1 (0.49) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL723608 | 0.75 | ADRB2 (0.41) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL7176303 | 0.75 | MEN1 (0.54) | MEN1KMT2AMAPTRAB9ALMNA | |
| SCHEMBL7179302 | 0.75 | KMT2A (0.50) | MEN1KMT2AMAPTRAB9ALMNA | |
| SCHEMBL18381553 | 0.75 | MEN1 (0.50) | MEN1KMT2AMAPTRAB9ALMNA | |
| SCHEMBL2631523 | 0.75 | PKM (0.45) | MEN1KMT2AKCNH2NOS2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912182-B2 | Viral polymerase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-12-16 | — | — | US | disclosed |
| US-8541402-B2 | Viral polymerase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-09-24 | — | — | US | disclosed |
| US-8476257-B2 | Viral polymerase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-02 | — | — | US | disclosed |