Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2670397 | 0.79 | RORC (0.46) | RORCSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL12167436 | 0.77 | SMN1; SMN2 (0.50) | RORCSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4748693 | 0.76 | RORC (0.48) | RORCSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4749403 | 0.76 | SMN1; SMN2 (0.50) | RORCSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL12167420 | 0.76 | SMN1; SMN2 (0.52) | RORCSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL1189044 | 0.76 | SMN1; SMN2 (0.52) | RORCSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL12492571 | 0.76 | SMN1; SMN2 (0.52) | RORCSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL13769237 | 0.76 | SMN1; SMN2 (0.52) | RORCSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL12167385 | 0.76 | SMN1; SMN2 (0.49) | RORCSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL9938502 | 0.75 | RORC (0.48) | RORCSMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097400-B1 | FUSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2013-07-03 | — | — | EP | disclosed |