Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10850136 | 0.82 | MAPT (0.45) | MAPTGAAALDH1A1RECQLCYP1A2 | |
| SCHEMBL14387512 | 0.82 | MAPT (0.45) | MAPTGAAKAT2BAPPCA12 | |
| SCHEMBL18236672 | 0.81 | MAPT (0.54) | MAPTGAAKAT2BTSHRALDH1A1 | |
| SCHEMBL21540394 | 0.79 | GAA (0.74) | MAPTGAAAPPALDH1A1RECQL | |
| SCHEMBL4813312 | 0.79 | FNTA (0.45) | MAPTGAAKAT2BALDH1A1HTT | |
| SCHEMBL19350615 | 0.78 | SIGMAR1 (0.43) | MAPTTSHRCA12CA1CA2 | |
| SCHEMBL4813329 | 0.76 | MAPT (0.48) | MAPTKAT2BTSHRALDH1A1RECQL | |
| SCHEMBL14558232 | 0.76 | POLB (0.45) | MAPTTSHRCA1CA2ALDH1A1 | |
| SCHEMBL33646 | 0.75 | MAPT (0.50) | MAPTGAATSHRKIF11APP | |
| SCHEMBL22175094 | 0.74 | MAPT (0.38) | MAPTGAAKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027124-B1 | IMIDAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | JANSSEN PHARMACEUTICA NV (BE) | 2013-07-03 | — | — | EP | disclosed |