Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | DUSP26 | Q9BV47 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239336 | 0.92 | MAPT (0.50) | MAPTPOLBTTRGFERKDM4E | |
| SCHEMBL1790490 | 0.90 | MAPT (0.63) | MAPTPOLBTTRGFERKDM4E | |
| SCHEMBL1792162 | 0.87 | MAPT (0.64) | MAPTPOLBTTRKDM4EALDH1A1 | |
| SCHEMBL1790293 | 0.85 | ALDH1A1 (0.64) | MAPTPOLBKDM4EALDH1A1MEN1 | |
| SCHEMBL1794991 | 0.85 | MEN1 (0.61) | MAPTPOLBTTRGFERKDM4E | |
| SCHEMBL16238872 | 0.82 | MAPT (0.55) | MAPTPOLBTTRGFERKDM4E | |
| SCHEMBL1791795 | 0.80 | TTR (0.76) | MAPTPOLBTTRGFERKDM4E | |
| SCHEMBL16238909 | 0.80 | TTR (0.69) | MAPTPOLBTTRGFERKDM4E | |
| SCHEMBL1792573 | 0.79 | MAPT (0.60) | MAPTPOLBTTRKDM4EALDH1A1 | |
| SCHEMBL1790836 | 0.78 | MAPT (0.64) | MAPTPOLBTTRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481001-B2 | Combination therapies comprising quinoxaline inhibitors of P13K-alpha for use in the treatment of cancer | EXELIXIS, INC. (US) | 2013-07-09 | — | — | US | disclosed |