Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | DUSP26 | Q9BV47 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15085668 | 0.92 | MAPT (0.53) | MAPTPOLBTTRGFERALDH1A1 | |
| SCHEMBL1792573 | 0.88 | MAPT (0.60) | MAPTPOLBTTRALDH1A1KDM4E | |
| SCHEMBL1792664 | 0.86 | CDC25A (0.60) | MAPTPOLBALDH1A1KDM4EMEN1 | |
| SCHEMBL15095999 | 0.84 | MEN1 (0.61) | MAPTPOLBTTRALDH1A1KDM4E | |
| SCHEMBL12292987 | 0.82 | MEN1 (0.54) | MAPTPOLBTTRGFERALDH1A1 | |
| SCHEMBL12372466 | 0.82 | TTR (0.50) | MAPTPOLBTTRGFERALDH1A1 | |
| SCHEMBL1795225 | 0.81 | TTR (0.72) | MAPTPOLBTTRGFERALDH1A1 | |
| SCHEMBL1790490 | 0.81 | MAPT (0.63) | MAPTPOLBTTRGFERALDH1A1 | |
| SCHEMBL1788225 | 0.81 | MAPT (0.56) | MAPTPOLBTTRALDH1A1KDM4E | |
| SCHEMBL23876430 | 0.79 | LMNA (0.58) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889664-B2 | Phosphatidylinositol 3-kinase inhibitors and methods of their use | EXELIXIS, INC. (US) | 2014-11-18 | — | — | US | disclosed |