Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16670160 | 0.88 | KDM4E (0.52) | KDM4EALDH1A1MAPTNPC1HPGD | |
| SCHEMBL16674817 | 0.81 | KDM4E (0.59) | GPR119KDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL15069376 | 0.80 | PRKCZ (0.60) | GPR119KDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL15065843 | 0.77 | GPR119 (0.46) | GPR119CHEK2MAOBHRH3 | |
| SCHEMBL15086426 | 0.77 | GPR119 (0.46) | GPR119CHEK2MAOBHRH3 | |
| SCHEMBL7455853 | 0.76 | GPR119 (0.59) | GPR119ALDH1A1KMT2AMEN1CHEK2 | |
| SCHEMBL381288 | 0.74 | KDM4E (0.67) | KDM4EALDH1A1MAPTNPC1HPGD | |
| SCHEMBL17981380 | 0.73 | PIK3CD (0.46) | GPR119CHEK2PRKCZHRH3PRMT5 | |
| SCHEMBL15069736 | 0.73 | KDM4E (0.48) | GPR119KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL15065810 | 0.73 | KDM4E (0.48) | GPR119KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013101974-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |