Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.42 |
| ▸ | BTK | Q06187 | 9/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18380748 | 0.93 | EGFR (0.41) | EGFRBTKRIPK1ABL1SRC | |
| SCHEMBL14706430 | 0.88 | EGFR (0.42) | EGFRBTKABL1KITSRC | |
| SCHEMBL14706422 | 0.87 | RIPK1 (0.41) | EGFRBTKRIPK1ABL1KIT | |
| SCHEMBL15087013 | 0.87 | SRC (0.43) | EGFRBTKABL1SRCFRK | |
| SCHEMBL18380727 | 0.86 | SRC (0.42) | EGFRBTKABL1KITSRC | |
| SCHEMBL14693540 | 0.86 | BTK (0.45) | EGFRBTKRIPK1ABL1KIT | |
| SCHEMBL14693537 | 0.86 | BTK (0.45) | EGFRBTKRIPK1ABL1KIT | |
| SCHEMBL15086974 | 0.86 | EGFR (0.41) | EGFRBTKRIPK1ABL1SRC | |
| SCHEMBL14706389 | 0.85 | SRC (0.41) | EGFRBTKABL1KITSRC | |
| SCHEMBL14693483 | 0.84 | BTK (0.45) | EGFRBTKRIPK1ABL1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9546172-B2 | Pyrazolo[3,4-d]pyrimidine and pyrazolo[2,3-d]pyrimidine compounds as kinase inhibitors | PHARMACYCLICS LLC (US) | 2017-01-17 | — | — | US | disclosed |
| US-9546172-B2 | Pyrazolo[3,4-d]pyrimidine and pyrazolo[2,3-d]pyrimidine compounds as kinase inhibitors | PHARMACYCLICS LLC (US) | 2017-01-17 | — | — | US | disclosed |
| WO-2013102059-A1 | PYRAZOLO [3, 4-D] PYRIMIDINE AND PYRROLO [2, 3-D] PYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |