Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 4/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4338104 | 0.88 | ALDH1A1 (0.38) | ALDH1A1KCNK3THRBCNR2BLM | |
| SCHEMBL21925692 | 0.88 | ALDH1A1 (0.38) | ALDH1A1KCNK3THRBCNR2BLM | |
| SCHEMBL16542295 | 0.73 | — | — | |
| SCHEMBL25873506 | 0.73 | TGFBR1 (0.35) | ALDH1A1KCNK3THRBCNR2BLM | |
| SCHEMBL9193899 | 0.73 | TGFBR1 (0.59) | ALDH1A1KCNK3THRBCNR2BLM | |
| SCHEMBL1231366 | 0.70 | — | — | |
| SCHEMBL2633929 | 0.70 | — | — | |
| SCHEMBL3306665 | 0.70 | — | — | |
| SCHEMBL4342682 | 0.70 | CNR2 (0.44) | ALDH1A1KCNK3THRBCNR2BLM | |
| SCHEMBL48766 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612853-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| EP-2609919-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2013-07-03 | — | — | EP | disclosed |