Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.44 |
| ▸ | RXRB | P28702 | 6/20 | 0.44 |
| ▸ | RXRG | P48443 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30078086 | 0.86 | RXRA (0.57) | RXRARXRBRXRGHPGDHDAC6 | |
| SCHEMBL15065675 | 0.86 | RXRA (0.57) | RXRARXRBRXRGHPGDHDAC6 | |
| SCHEMBL15065516 | 0.79 | KMT2A (0.63) | RXRAHDAC6LMNAPPIAALDH1A1 | |
| SCHEMBL30078173 | 0.79 | KMT2A (0.63) | RXRAHDAC6LMNAPPIAALDH1A1 | |
| SCHEMBL30078118 | 0.76 | RXRA (0.53) | RXRARXRBRXRGHPGDMAPT | |
| SCHEMBL15066327 | 0.76 | RXRA (0.53) | RXRARXRBRXRGHPGDMAPT | |
| SCHEMBL1178876 | 0.75 | LTA4H (0.58) | PPIAALDH1A1MAPTKMT2AFOLH1 | |
| SCHEMBL29953305 | 0.74 | KMT2A (0.66) | RXRARXRBRXRGHPGDALDH1A1 | |
| SCHEMBL6341223 | 0.74 | KMT2A (0.66) | RXRARXRBRXRGHPGDALDH1A1 | |
| SCHEMBL30078103 | 0.73 | MRGPRX4 (0.60) | RXRARXRBHPGDPPIAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013102145-A1 | SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |