Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15067203 | 0.86 | HRH4 (0.45) | HRH4HRH3KDM4EALDH1A1PSMB1 | |
| SCHEMBL15088637 | 0.86 | HRH4 (0.45) | HRH4HRH3KDM4EALDH1A1PSMB1 | |
| SCHEMBL1186911 | 0.81 | MEN1 (0.52) | MEN1KMT2A | |
| SCHEMBL15069831 | 0.80 | LMNA (0.46) | HRH4HRH3KDM4EALDH1A1PSMB1 | |
| SCHEMBL11767308 | 0.76 | ELANE (0.52) | HRH4ALDH1A1MEN1KMT2A | |
| SCHEMBL17666631 | 0.76 | KMT2A (0.41) | MEN1KMT2A | |
| SCHEMBL15088680 | 0.75 | KMT2A (0.39) | HRH4HRH3KDM4EALDH1A1PSMB1 | |
| SCHEMBL21780925 | 0.75 | MEN1 (0.47) | ALDH1A1MEN1KMT2A | |
| SCHEMBL5725421 | 0.75 | LSS (0.49) | KDM4EALDH1A1ACHEMEN1KMT2A | |
| SCHEMBL15067474 | 0.75 | MEN1 (0.47) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9309211-B2 | Arylalkene derivatives and use thereof as selective estrogen receptor modulators | CENTAURUS BIOPHARMA CO., LTD. (CN) | 2016-04-12 | — | — | US | disclosed |
| WO-2013097773-A1 | NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | CENTAURUS BIOPHARMA CO., LTD. (CN) | 2013-07-04 | — | — | WO | disclosed |