SCHEMBL15088926

SCHEMBL15088926

c1ccc(-c2ccc3c(c2)c2cc4c(cc2n3-c2cc(-c3cccnc3)ccn2)N(c2cc(-c3cccnc3)ccn2)c2cccc3c(-c5ccccc5)ccc-4c23)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 2/20 0.40
CYP11B1 P15538 3/20 0.33
CYP11B2 P19099 3/20 0.33
COMT P21964 1/20 0.33
PDE4A P27815 3/20 0.33
PDE4B Q07343 3/20 0.33
PDE4C Q08493 3/20 0.33
PDE4D Q08499 3/20 0.33
PDE3B Q13370 3/20 0.33
PDE3A Q14432 3/20 0.33
PDE5A O76074 2/20 0.33
ATM Q13315 1/20 0.32
CYP3A4 P08684 3/20 0.32
LMNA P02545 2/20 0.32
CYP1A2 P05177 2/20 0.32
MAPK1 P28482 2/20 0.32
HIF1A Q16665 2/20 0.32
RAF1 P04049 1/20 0.32
PRKDC P78527 1/20 0.31
PSEN1 P49768 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15088868 0.94 PIK3CA (0.37) PIK3CACOMT
SCHEMBL15088834 0.91 PIK3CA (0.37) PIK3CACYP11B1CYP11B2ATMCYP3A4
SCHEMBL15088815 0.90 PIK3CA (0.36) PIK3CACYP11B1CYP11B2COMTPDE4A
SCHEMBL15088902 0.89 CYP19A1 (0.39) PIK3CACYP11B1CYP11B2LMNAPRKDC
SCHEMBL15088869 0.88 PIK3CA (0.33) PIK3CACOMT
SCHEMBL15088917 0.88 CYP19A1 (0.34) PIK3CAPRKDCCYP19A1
SCHEMBL15088903 0.85 CYP19A1 (0.38) PIK3CACYP11B1CYP11B2COMTPDE4A
SCHEMBL15088787 0.85 CYP11B1 (0.35) PIK3CACYP11B1CYP11B2COMTPDE4A
SCHEMBL15088804 0.84 MEN1 (0.35) PIK3CALMNAMAPK1ALDH1A1HSD17B10
SCHEMBL15089198 0.84 COMT (0.32) COMTMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013100497-A1 ORGANIC LIGHT-EMITTING COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME 주식회사 두산 (KR) 2013-07-04 WO disclosed